Are topical corticosteroids useful in phototherapy for psoriasis?
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Cited by (47)
Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model
2022, European Journal of Medicinal ChemistryCitation Excerpt :Due to the complex etiology of psoriasis, existing treatments for psoriasis are mainly based on symptom control. Mild or limited psoriasis is treated with topical corticosteroids [9] and/or vitamin D analogues [10]. Moderate to severe and/or extensive psoriasis may require phototherapy, and systemic agents such as oral retinoids [11], methotrexate [12,13], biological agents [14], cyclosporine [15–17] or apremilast [18].
Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis with phototherapy
2019, Journal of the American Academy of DermatologyPhototherapy: Kids are not just little people
2015, Clinics in DermatologyCitation Excerpt :Although topical corticosteroids are often used in conjunction with UVB therapy in psoriasis, there are few reliable studies documenting superior outcomes in patients treated with combination therapy compared with phototherapy alone. A prospective, randomized, double blind, placebo-controlled trial compared UVB plus potent topical corticosteroids to UVB plus placebo cream in 53 adult patients with psoriasis.27 Although there was a non-significant trend towards more rapid clearance in the corticosteroid treated group, the 2 groups had nearly identical rates of clearance with no difference in the number of treatments needed to achieve clearance.
Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy
2010, Journal of the American Academy of DermatologyCitation Excerpt :Early trials demonstrated a more rapid clearing of psoriasis when UVB was used in conjunction with topical fluocinolone or clobetasol propionate (used in combination with UVB and topical anthralin).55 However, other studies failed to demonstrate a benefit in either the clearance or the remission rate, and some studies suggest that the use of topical corticosteroids in conjunction with UV therapy may be associated with a higher relapse rate.56-58 Thus, it is unclear whether the use of topical steroids in combination with UVB is beneficial.59
Safety considerations with combination therapies for psoriasis
2020, Expert Opinion on Drug Safety
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From the Department of Dermatology and the Charles A. Dana Research Laboratories, Beth Israel Hospital and Massachusetts General Hospital, Harvard Medical School.
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Recipient of a McLaughlin Research Fellowship from Canada during this study.