Original investigation: transplantationUrinary actin, interleukin-6, and interleukin-8 may predict sustained arf after ischemic injury in renal allografts
Section snippets
Subjects
The subjects comprised 30 consecutive consenting recipients of a cadaveric renal allograft (CAD), and 10 recipients of a living donor kidney (LD) who never had an episode of acute rejection or other medical and surgical complications during the first 2 posttransplant weeks. Informed consent was obtained for a postoperative study of renal allograft function and damage approved previously by Indiana University-Purdue University in Indianapolis and Clarian Institutional Review Boards. Patient age
Clinical features
Clinical characteristics of the allografts and patient population are summarized in Table 1. Gender and age distribution of patients were similar in the cadaveric allograft groups displaying sustained ARF and recovery and the living donor group. Total and warm ischemic times did not differ significantly between sustained ARF and recovery groups (1,706.2 ± 146.5 versus 1,664.4 ± 53.1 min and 34.8 ± 2.0 versus 36.9 ± 1.3 min, respectively).
Renal function
Subjects were classified into the sustained ARF or
Discussion
Clinical parameters that are obtained easily and reliably and reflect the ongoing pathophysiologic status of the kidney may facilitate improved management and decrease morbidity and mortality in ARF. In this study, we analyzed daily urine samples from recipients of a renal allograft to determine potential markers of renal injury and inflammation. Ischemic insult to the kidney often results in damage to cells of nephron and renal vasculature. Cells are lost through the processes of necrosis and
Acknowledgements
The authors thank Serafina K. Salamo, Stacy Vulgamott, and Seok-Min Hong for technical assistance.
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Cited by (0)
This study was supported by Department of Medicine, Indiana University School of Medicine.