Phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport
References (23)
- et al.
Calcium and phospholipid-dependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds
Biochem. Biophys. Res. Commun.
(1984) Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor
J. Steroid Biochem. Mol. Biol.
(1994)- et al.
In vitro effects of natural plant polyphenols on the proliferation of normal and abnormal human lymphocytes and their secretions of interleukin-2
Cancer Lett.
(1993) - et al.
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors
Exp. Cell Res.
(1993) - et al.
Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II
Biochem. Biophys. Res. Commun.
(1993) - et al.
The protein kinase inhibitor staurosporine induces morphological changes typical of apoptosis in Mort-4 cells without concomitant DNA fragmentation
Biochem. Biophys. Res. Commun.
(1993) - et al.
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors
Exp. Cell Res.
(1994) - et al.
Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity
Biochem. Biophys. Res. Commun.
(1996) - et al.
Prevention of the TPA-mediated down-regulation of protein kinase C
Biochem. Biophys. Res. Commun.
(1988) - et al.
Genistein, a specific inhibitor of tyrosine-specific protein kinases
J. Biol. Chem.
(1987)
Quercetin inhibits hexose transport in a human diploid fibroblast
J. Membr. Biol.
Cited by (91)
Palladium-Catalyzed Multicomponent Cascade Reaction of 3-Hydroxypropionitrile: Synthesis of Substituted Dihydrochalcones
2023, Journal of Organic ChemistryInnovative hydrogel containing polymeric nanocapsules loaded with phloretin: Enhanced skin penetration and adhesion
2021, Materials Science and Engineering CCitation Excerpt :In contrast, at concentrations of 20 or 50 μM, less than 2% inhibition of cell growth occurred. In another study, 150 μM phloretin induced apoptosis in approximately 95% of B16 mouse melanoma 4A5 after 24 h [54]. The results presented here are based on cell treatment using 10 μM phloretin, which suggests the superiority of the nanocapsules.
Dermatological applications of the flavonoid phloretin
2020, European Journal of PharmacologyCitation Excerpt :The inhibition of glucose trans-membrane transport by phloretin at different concentrations was also shown in erythrocytes of diabetic patients (Hu et al., 2000) as well as human liver cancer cells (Wu et al., 2009) and breast cancer cells (Wu et al., 2018). In addition, phloretin (0.15 mM) inhibited about 75% of protein kinase C activity in B16 melanoma 4A5 cells (Kobori et al., 1997). This is important because downregulation of protein kinase C activity induces apoptosis.
Atmospheric hydrogenation of Α Β-unsaturated ketones catalyzed by highly efficient and recyclable Pd nanocatalyst
2019, Catalysis CommunicationsCitation Excerpt :Selective hydrogenation of α, β-unsaturated ketones is an important catalytic process in organic synthesis and industrial production [1–4]. And the selective hydrogenation of the CC bond functional group is a significant method for the production of saturated ketones, which are key intermediates for synthesizing biologically active compounds such as HIV-I protease inhibitors [5,6]. In recent years, although non-noble transition metal like copper was investigated as an economical catalyst alternative [7], much more studies have still used different noble transition metal catalysts for this kind reaction, such as Ru [8,9], Pt [10,11], Ir [12,13], Pt/Re [14], Au [15,16], and Pd [4,17–20].
- 1
Current address: National Research Institute of Fisheries Sciences, Ministry of Agriculture, Forestry and Fisheries, 2-12-4 Fukuura, Yokohama, Kanagawa 236, Japan.