Increased cortical expression of the orexin-1 receptor following permanent middle cerebral artery occlusion in the rat
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Cited by (35)
Role of orexin-A in experimental autoimmune encephalomyelitis
2016, Journal of NeuroimmunologyCitation Excerpt :OX-A also can alleviate cognitive deficits produced by sleep deprivation (Deadwyler et al., 2007) and inactivation of OX1R impairs spatial learning and memory (Akbari et al., 2006). Loss of orexinergic neurons or dysfunction in the orexinergic system have been observed in several acute and chronic CNS diseases such as Alzheimer (Fronczek et al., 2012), narcolepsy (Arango et al., 2014), an animal model for Parkinson's disease (Long-Biao et al., 2010) and stroke (Irving et al., 2002). The reported findings about orexinergic system and MS are controversial.
Effects of changes in energy homeostasis and exposure of noxious insults on the expression of orexin (hypocretin) and its receptors in the brain
2013, Brain ResearchCitation Excerpt :Four of the 5 studies of ischemia, showed increased OxR1 expression (Table 3). Yet, it is important to note that this change was specific to hippocampal and cortical regions, not the hypothalamus, in keeping with the sensitivity of these regions to hypoxic damage (given their greater blood supply) (Irving et al., 2002). One study used middle cerebral occlusion to induce ischemia and reported a decrease in OxA expression in the hypothalamus (Kitamura et al., 2010).
Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model
2012, Neuroscience LettersCitation Excerpt :While OxA signaling promotes SPA [21,22,44], and increased SPA protects against obesity [43,44], whether OxA protects against HFD-induced oxidative stress in the hypothalamus is unknown. Multiple models link changes in OxA or orexin receptors to neurodegenerative conditions [13,17], suggesting that orexin signaling pathways help maintain neuronal survival. Increased survival of neurons responsible for mediating SPA might explain the long-term benefits of OxA in obesity resistance, but how OXA-induced intracellular mechanisms affect short-term neuronal survival or SPA response is poorly understood.
Ischemic stroke and glucose intolerance: A review of the evidence and exploration of novel therapeutic targets
2012, Journal of Pharmacological SciencesEffect of orexin-A on post-ischemic glucose intolerance and neuronal damage
2011, Journal of Pharmacological SciencesThe effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia
2010, Neuroscience Research