Elsevier

Neuroscience Letters

Volume 279, Issue 1, 21 January 2000, Pages 1-4
Neuroscience Letters

Migraine in childhood – are periodically occurring migraine attacks related to dynamic changes of cortical information processing?

https://doi.org/10.1016/S0304-3940(99)00924-6Get rights and content

Abstract

Amplitudes and habituation of contingent negative variation (CNV) were analyzed in relation to spontaneously occurring migraine attacks in ten children suffering from migraine without aura. Recording took place during feedback training and instrumental conditioning of slow brain potentials. Both the amplitude of the early CNV component and its habituation deficit increase during the 5 days prior to a migraine attack, with maximum abnormalities the day before the ictal episode. Abrupt reduction of the amplitude and normalization of the CNV habituation were observed during the attack. This study provides evidence for neurophysiological periodicity in young migraineurs and emphasizes that the time relative to the migraine attacks must be considered in studies of juvenile migraine during the headache-free period.

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Acknowledgements

This study was supported by the German Research Foundation Grant Ge 500/4-1, 4-2.

References (17)

  • P Kropp et al.

    Prediction of migraine attacks using a slow cortical potential, the contingent negative variation

    Neurosci. Lett.

    (1998)
  • P Kropp et al.

    Migraine-evidence for a disturbance of cerebral maturation in man?

    Neurosci. Lett.

    (1999)
  • N Birbaumer et al.

    Slow potentials of the cerebral cortex and behavior

    Physiol. Rev.

    (1990)
  • K.B.E Böcker et al.

    Contingent negative variation in migraine

    Headache

    (1990)
  • S Evers et al.

    Event-related potentials (P300) in primary headache in childhood and adolescence

    J. Child Neurol.

    (1998)
  • S Evers et al.

    Dynamic changes of cognitive habituation and serotonin metabolism during the migraine interval

    Cephalalgia

    (1999)
  • Classification and diagnostic criteria for headache disorders, cranial neuralgia, and facial pain

    Cephalalgia

    (1988)
  • P Kropp et al.

    Contingent negative variation during migraine attack and interval: evidence for normalization of slow cortical potentials during the attack

    Cephalalgia

    (1995)
There are more references available in the full text version of this article.

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