Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus–globus pallidus network
Section snippets
Experimental procedures
Experimental procedures were carried out on adult male Sprague–Dawley rats (Charles River, Margate, UK) and were conducted in accordance with the Animals (Scientific Procedures) Act, 1986 (UK).
Location of recorded neurones
After physiological characterisation, juxtacellular microiontophoresis led in each case to a single neurone being well labelled (Fig. 1A, B): 46 of 181 recorded neurones were labelled using this technique. The locations of the remainder were determined directly from extracellular deposits of Neurobiotin or inferred from the stereotaxic position of the recorded unit relative to deposits or juxtacellularly labelled neurones. All regions of the STN and the rostral half of the GP were sampled in
The more intense LFO activity in the STN–GP network following dopamine depletion is driven predominantly by the cortex
The EEGs of rats anaesthetised with urethane were dominated by a low-frequency oscillation (∼1 Hz) that was similar in form to that described previously in naturally sleeping or anaesthetised rats, cats and humans (Steriade et al., 1993c, Steriade et al., 1996, Achermann and Borbély, 1997, Amzica and Steriade, 1998, Steriade and Amzica, 1998, Magill et al., 2000, Urbain et al., 2000). The slow oscillation is generated by synchronous, rhythmic depolarising (active component) and hyperpolarising
Acknowledgements
This work was supported by the Medical Research Council UK and the European Community (BIOMED 2 project Grant BMH4-CT-97-2215). P.J.M. was in receipt of a Medical Research Council studentship. We gratefully acknowledge Dr. Y. Kaneoke for the provision of the oscillation detection algorithm and Dr. E.A. Stern for the correlation analysis routines. We thank Caroline Francis for expert technical assistance and Paul Jays for image processing.
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