Metastasizing Uterine Leiomyoma: A Case with Cardiac and Pulmonary Metastasis
References (17)
Mitosis counts: Reproducibility and significance in grading of malignancy
Hum Pathol
(1986)Reproducibility of the mitosis count in the histologic diagnosis of smooth muscle tumors of the uterus
Hum Pathol
(1976)- et al.
Intravenous leiomyomatosis of the uterus with extension into the heart
Am J Med
(1980) - et al.
Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma
N Engl J Med
(1981) - et al.
Pregnancy complicated by metastasizing leiomyoma of the uterus
Obstet Gynecol
(1973) Typical fibromyoma of the abdominal wall following hysterectomy
Ann Surg
(1921)- et al.
Multiple pulmonary (hamartomatous?) leiomyomas
Light and electron microscopic study. Virchows Arch (Pathol Anat)
(1981) - et al.
Leiomyomatous neoplasms of the lung: A clinical, histologic, and immunohistochemical study
Modern Pathol
(1989)
Cited by (60)
Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature
2019, Respiratory Medicine Case ReportsCitation Excerpt :One theory suggests that BMLs are primary pulmonary lesions that represent multifocal leiomyomatosis [14] while others contend that they represent metastases. Some have suggested hematogenous extension following uterine surgical procedures [16], but presence of BML in the absence of such invasive procedures, including in our case, makes this a less likely etiology. The possibility of BML representing a metastasis from a low grade uterine leiomyosarcoma has also been entertained, but the histology and the molecular studies in which distinct signatures are noted only for uterine leiomyomas and BMLs makes this unlikely.
Multiple Primary Leiomyomas in the Right Ventricle: A Rare Form of Leiomyoma
2016, Annals of Thoracic SurgeryCitation Excerpt :There are only 3 female and 2 male cases reported in the English literature. The origins of the first 2 female cases [2–3] were identified as metastases, and the third female case [4] and 2 male cases [5–6] were identified as primary lesions. In adult women, if independent leiomyomas exist inside the pathway of the lower half of the venous system including the inferior vena cava, heart, pulmonary artery, and lungs, BMLs from uterine leiomyomas should be considered first.
Right ventricular and epicardial tumors from benign metastasizing uterine leiomyoma
2016, Journal of Thoracic and Cardiovascular SurgeryBenign metastasizing leiomyomatosis of the lungs presenting a miliary pattern
2014, Annals of Thoracic SurgeryCitation Excerpt :A similar pattern of presentation of BML is also reported in this case. The pathogenesis of BML is unclear, although it has been postulated that antegrade metastasis through venous channels can occur to extrauterine organs, such as the heart and the lungs, during surgical manipulation of a uterine leiomyoma [8]. Although the patient we report with miliary presentation is posthysterectomy, cases of BML, including the patient reported by Lipton and colleagues [1], have been discovered even before resection of a uterine leiomyoma [4].
Novel hormone treatment of benign metastasizing leiomyoma: An analysis of five cases and literature review
2013, Fertility and SterilityCitation Excerpt :In one patient, histological diagnosis may have been associated with significant morbidity, given the close proximity of the lung nodules to the heart (case 1). Another case demonstrates the reported close pathogenesis between IVL and BML, as the patient presented with an IVC/cardiac tumor consistent with IVL as well as pulmonary lesions consistent with BML (5, 42, 43) (case 4). This case series suggests that hormone therapy may be used in the treatment of BML, specifically by employing synergistic combinations with individual dosing.
Other Neoplastic Lesions: Benign and Malignant
2010, Medical Management of the Thoracic Surgery Patient
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Yoshiki Takatsu, M.D., Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsu-cho, Amagasaki-shi, tIyogo 660, Japan, Tel.: 06-482-1521, Fax: 06-482-7430