International Journal of Radiation Oncology*Biology*Physics
Results of conservative surgery and radiation for mammographically detected ductal carcinoma in situ (DCIS)
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Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer
2015, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :The treatment of DCIS typically consists of surgery, radiation, and when necessary, hormonal therapy. Despite the effective treatment regimen and initial response to therapy, approximately 15% of patients with DCIS will relapse [2]. Additionally, 30–50% of DCIS cases will progress to invasive ductal carcinoma (IDC) if left untreated [3,4].
Breast Cancer: Stages I-II
2015, Clinical Radiation OncologyCharacterization of a stem-like subpopulation in basal-like ductal carcinoma in situ (DCIS) lesions
2014, Journal of Biological ChemistryCitation Excerpt :Therapeutic management of DCIS involves surgery, radiation, and where appropriate, hormonal therapies (1). Roughly 15% of patients with DCIS show recurrent disease following therapy (2). Identifying which patients are at greatest risk for disease recurrence and progression to invasive disease is a critical issue facing clinicians.
Does molecular biology play any role in ductal carcinoma in situ?
2013, Gynecologie Obstetrique et FertiliteFactors associated with residual disease after initial breast-conserving surgery for ductal carcinoma in situ
2012, Human PathologyCitation Excerpt :Tumor size remained as a greatly controversial factor [9,13,20,21]. Of potential prognostic factors, margin status has been given the most attention in regard to the success of BCS for DCIS, although its association with recurrence was variable [3-6,9,10,13,22-30]. Although consensus regarding optimal margin width is lacking, a margin threshold of 2 mm has been generally accepted by most North American radiation oncologists when BCS is combined with radiation therapy [2].
Breast Cancer: Stages I and II
2012, Clinical Radiation Oncology: Third Edition