Sleep disturbance in children with growth hormone deficiency
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Cited by (32)
Is growth hormone deficiency associated with anxiety disorder and depressive symptoms in children and adolescents?: A case-control study
2018, Growth Hormone and IGF ResearchCitation Excerpt :Recent studies have suggested that growth hormone (GH) also affects some psychological processes. Children with growth hormone deficiency (GHD) have been reported to experience sleep disorders, failure to mature psychologically and impaired personality development [6, 7]. Failure to thrive, behavioral problems, lack of confidence in social life and depressive symptoms are noteworthy in children with GHD [8, 9].
Effects of replacement therapy on sleep architecture in children with growth hormone deficiency
2012, Sleep MedicineCitation Excerpt :The studies of the effects of GH replacement on sleep structure have shown conflicting results and, in general, they have reported only scarce effects on subjective and objective sleep parameters [3,4]. A partial normalization of total sleep time and slow-wave sleep (SWS) has been described in GH-deficient (GHD) adults [5] and a partial normalization of REM sleep has been reported in GHD children [6]. On the contrary, no effects have been reported on total sleep time or time spent in different sleep stages, or on daytime sleep propensity, measured by means of the multiple sleep latency test [7].
Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)
2010, Frontiers in NeuroendocrinologyCitation Excerpt :Moreover, functional alterations in the somatotrope axis can lead to marked changes in the regulation of sleep-wake activity: GH deficiency in children is often associated with decreases in REM sleep [104,304,315] and animal models of altered GH status, such as dwarf Lewis rats [214] and transgenic GH-mice [323], show sleep impairment. Although the nature of the hypothalamic mechanisms through which the different components of GH-axis influences sleep is poorly understood, several possibilities have been put forward, involving direct effects of GH [104,214,305] SST [61,62] or GHRH [77,214]. In this sense, one interesting possibility is that GHRH neurons in the PVH, which play a major role in sleep control, stimulate REM sleep patterns [296,297].
Growth failure and sleep disordered breathing: A review of the literature
2006, International Journal of Pediatric OtorhinolaryngologyThe Somatotropic Axis in Psychologic Functioning. Effects on Sleep and Psychopathology
2006, The Somatotrophic Axis in Brain FunctionPsychological Importance to the Child of Growth Hormone Replacement
2006, The Somatotrophic Axis in Brain Function