Original contributionCreatine phosphokinase elevation in patients presenting to the emergency department with cocaine-related complaints
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Cited by (25)
Abuse potential and toxicity of the synthetic cathinones (i.e., “Bath salts”)
2020, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Although peripheral in nature, cardiac symptoms may result from overstimulation of adrenoreceptors in the CNS, indirectly triggering alterations in cardiovascular function (for a review, see Carvalho et al., 2012). Rhabdomyolysis may contribute to myocardial damage (Benzer et al., 2013; Eiden et al., 2013; Imam et al., 2013; Sivagnanam et al., 2013; Sutamtewagul et al., 2014), as is the case for other psychostimulants (Counselman et al., 1997). Hepatoxicity has been frequently reported in cases of synthetic cathinone overdose.
Polysubstance abuse and rhabdomyolysis
2020, Toxicology Cases for the Clinical and Forensic LaboratoryQuantification of endogenous neurotransmitters and related compounds by liquid chromatography coupled to tandem mass spectrometry
2019, TalantaCitation Excerpt :Thus, both psychostimulants produced a strong increment in Creat brain concentrations (around 5-folds, see Fig. 3a), which was also reported in the urine of an intoxicated consumer of MDPV [32]. Additionally Cr concentrations were 2-fold boosted after COCA injection (Fig. 3a), which could be related with the incidence of rhabdomyolysis syndrome after COCA ingestion [33,34]. Moreover, an extensive increase in choline concentrations (5–7 fold, see Fig. 3b) was observed in hippocampus, in agreement with the reduction of the Ch acetyltransferase activity described after COCA administration [35].
Excited delirium following use of synthetic cathinones (bath salts)
2012, General Hospital PsychiatryCitation Excerpt :The co-occurrence of this constellation of symptoms has been previously described associated with multiple drugs with actions on central dopamine. Specifically, use of cocaine [8,9], phencylidine (PCP) [10], MDMA (ecstasy) [11] and methamphetamine [12] has been reported to produce an agitated delirium with skeletal muscle damage proceeding in a some cases to renal failure and death. This syndrome, labeled “excited delirium” [14], presents clinicians with a challenge to management as interventions commonly used to control disorganized and violent behavior, i.e., physical restraints, electronic control devices (TASER) or antipsychotic drugs, have the potential to exacerbate the pathophysiological changes that contribute to severe medical complications.
Cocaine-associated chest pain
2005, Emergency Medicine Clinics of North AmericaCitation Excerpt :Because cocaine produces increased motor activity, hyperthermia, skeletal muscle injury, and rhabdomyolysis, creatine kinase and CK-MB may not be as useful in detecting cardiac injury and MI in this patient population [18,101]. Counselman and colleagues [102] studied 40 patients presenting to an urban ED with any complaint related to cocaine use within the preceding 24 hours (excluding seizures) to determine the incidence of creatine kinase elevations. Twenty-one of the 40 patients (53%) had elevated creatine kinase levels, with mean creatine kinase levels for these patients of 1071 IU/L. No statistically significant difference existed between the patient's initial complaint (musculoskeletal, psychiatric, or cardiovascular) and the incidence of creatine kinase elevation, indicating that some degree of skeletal muscle injury and creatine kinase elevation appear to be common in patients using cocaine.