VISCOSUPPLEMENTATION THERAPY WITH INTRA-ARTICULAR HYALURONIC ACID: Fact or Fantasy?
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Cited by (47)
Viscosupplementation for treating knee osteoarthrosis: Review of the literature
2015, Revista Brasileira de OrtopediaThe effects of high molecular weight hyaluronic acid (Hylan G-F 20) on experimentally induced temporomandibular joint osteoartrosis: Part II
2011, International Journal of Oral and Maxillofacial SurgeryCitation Excerpt :It has been reported that exogenous HA molecules with molecular weight greater than 5.4 × 105 Da stimulate the synthesis of endogenous HA, but the strongest stimulation was observed in molecular weight between 6.2 × 105 and 3.8 × 106 Da3,30. In in vitro studies, although HA of molecular weight 5 × 106 to 6 × 106 Da was reported to increase the synthesis of endogenous HA, a molecular weight between 5 × 105 and 7 × 105 Da did not show similar effects29,30. Five injections were required for the effective treatment of low molecular weight HA whereas HMWHA was reported to be effective with a smaller number of intra-articular injections.
The Role of Viscosupplementation in the Ankle Using Hylan G-F 20
2008, Journal of Foot and Ankle SurgeryCitation Excerpt :A number of other authors also agree with this claim, and suggest that the cytoprotective activities of high molecular weight hylans are dependent on both the concentration and the molecular weight of hyaluronan in the joint (10–15). Still further, it has been shown that synovial cells obtained from patients with osteoarthritis show an increased amount of hyaluronan synthesized in culture when exposed to exogenous high molecular weight hyaluronan (5 to 6 × 106 daltons) (13), whereas hyaluronan of low molecular weight (5 to 7 × 105 daltons) does not induce the same beneficial response (28). Viscosupplementation conveys a number of direct and indirect effects that are associated with normalization of the rheological properties of synovial fluid.
Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee - A prospective randomized clinical trial
2008, KneeCitation Excerpt :The rationale of intra articular injection of HA in the osteoarthritic joint is to restore the viscoelastic properties [5–8]. The therapeutic efficacy and safety of intra articular injection of HA in the treatment of osteoarthritis of the knee has been well established in the literature [9–16]. A recent Cochrane review has concluded in favour of HA class products in the treatment of OA of the knee [17].
Osteoarthritis
2008, Essentials of Physical Medicine and RehabilitationOsteoarthritis
2008, Essentials of Physical Medicine and Rehabilitation: Musculoskeletal Disorders, Pain, and Rehabilitation, Second Edition
Address reprint requests to Lee S. Simon, MD, Department of Medicine, Harvard Medical School, Harvard University, Lowry Medical Office Building, 110 Francis Street, Suite 5A, Boston, MA 02115
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Department of Medicine, Division of Rheumatology and Metabolic Bone Disease, Harvard Medical School; Beth Israel Deaconess Medical Center; and Medical Service (Arthritis Unit), Massachusetts General Hospital, Boston, Massachusetts