Clinical and Immunologic Aspects of the Hyperimmunoglobulin E Syndrome
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Factors Determining Bone Mineral Density in Patients with Biliary Atresia after a Successful Kasai Operation
2017, Pediatrics and NeonatologyCitation Excerpt :The results indicated that bone disease in lck-IL-4 mice appeared to result from decreased bone formation by marked atrophy of osteoblasts in lck-IL-4 bone tissue. Osteoporosis is also a common complication in immunodeficiency patients with hyper-IgE syndrome exposed to excess IL-4,29 therefore it is plausible that circulating IL-4 can contribute to bone loss in patients with biliary atresia, although the precise mechanism is not known. In conclusion, hepatic osteodystrophy is a common complication in patients with biliary atresia even if they are nonjaundiced.
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