Clinical and Immunologic Aspects of the Hyperimmunoglobulin E Syndrome

https://doi.org/10.1016/S0889-8588(18)30632-4Get rights and content

The hyperimmunoglobulin E (HIE) syndrome is a complex disorder characterized by markedly elevated serum IgE levels, chronic dermatitis, and serious recurrent infections.

This article reviews the clinical and laboratory manifestations of the HIE syndrome and relates them to the underlying immunologic abnormalities found in this syndrome.

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