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Cognitive patterns in subtypes of schizophrenia

Published online by Cambridge University Press:  16 April 2020

P. Brazo ,
R.M. Marié ,
I. Halbecq ,
K. Benali ,
L. Segard ,
P. Delamillieure ,
S. Langlois-Théry ,
A. Van Der Elst ,
F. Thibaut  and
M. Petit
...Show all authors
P. Brazo
Affiliation:
Centre Esquirol, Centre Hospitalier Universitaire (CHU), Avenue Côte de Nacre, 14033 Caen, France Groupe d’Imagerie Neurofonctionnelle, UMR 6095 CNRS, CEA, Université de Caen, Université Paris V, France
R.M. Marié
Affiliation:
INSERM U320, Centre Cycéron, 14000 Caen, France
I. Halbecq
Affiliation:
Centre Esquirol, Centre Hospitalier Universitaire (CHU), Avenue Côte de Nacre, 14033 Caen, France Groupe d’Imagerie Neurofonctionnelle, UMR 6095 CNRS, CEA, Université de Caen, Université Paris V, France
K. Benali
Affiliation:
Groupe d’Imagerie Neurofonctionnelle, UMR 6095 CNRS, CEA, Université de Caen, Université Paris V, France
L. Segard
Affiliation:
Centre Hospitalier du Rouvray, 76301, Sotteville les Rouen, France
P. Delamillieure
Affiliation:
Centre Esquirol, Centre Hospitalier Universitaire (CHU), Avenue Côte de Nacre, 14033 Caen, France Groupe d’Imagerie Neurofonctionnelle, UMR 6095 CNRS, CEA, Université de Caen, Université Paris V, France
S. Langlois-Théry
Affiliation:
Centre Hospitalier du Rouvray, 76301, Sotteville les Rouen, France
A. Van Der Elst
Affiliation:
Centre Hospitalier du Rouvray, 76301, Sotteville les Rouen, France
F. Thibaut
Affiliation:
Centre Hospitalier du Rouvray, 76301, Sotteville les Rouen, France Unité INSERM EPI-9906, Université de Rouen, CHU Charles Nicolle, 76000, Rouen, France
M. Petit
Affiliation:
Centre Hospitalier du Rouvray, 76301, Sotteville les Rouen, France Unité INSERM EPI-9906, Université de Rouen, CHU Charles Nicolle, 76000, Rouen, France
S. Dollfus*
Affiliation:
Centre Esquirol, Centre Hospitalier Universitaire (CHU), Avenue Côte de Nacre, 14033 Caen, France Groupe d’Imagerie Neurofonctionnelle, UMR 6095 CNRS, CEA, Université de Caen, Université Paris V, France
*
*Corresponding author. Fax: +33-2-31-06-49-87. E-mail address: dollfus-s@chu-caen.fr (S. Dollfus).
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Summary

Aim

Because of the heterogeneity of schizophrenia, this study researched different cognitive patterns in distinct subtypes of schizophrenic patients.

Methods

Thirty-five Diagnostic and Statistical Manual IV (DSM IV) schizophrenic patients and 35 healthy controls were included. Patients were categorized into deficit, disorganized and positive subtypes with the schedule for the deficit syndrome (SDS) and the positive and negative syndrome scale (PANSS). Executive/attentional functions were assessed with the modified card sorting test (MCST), a test of verbal fluency, the trail making test (TMT) and the Stroop color-word test (Stroop test). Episodic memory was explored through the California verbal learning test (CVLT).

Results

The positive subtype had some executive/attentional (fluency and Stroop tests) and mnesic performances in the normal range, suggesting the preservation of good cognitive skills. In contrast, the deficit and disorganized subtypes had major mnesic and executive/attentional dysfunctions compared to healthy subjects. The deficit subtype compared to the control group performed predominantly worse on the MCST and fluency, whereas the disorganized subtype had the lowest scores on the TMT and the Stroop test.

Conclusion

This study showed distinct cognitive patterns in deficit, disorganized and positive patients in comparison with the controls, suggesting a heterogeneous cognitive dysfunction in schizophrenia.

Keywords

Executive/attentional cognitive functionsEpisodic memorySchizophrenic subtypesDisorganized, positive and deficit syndromesNeuropsychologyNeuropsychological tests
Type
Original Article
Information
European Psychiatry , Volume 17 , Issue 3 , May 2002 , pp. 155 - 162
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS. 2002

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