Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats
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Cited by (11)
Oral vitamin B1-substitution does not decrease genetically determined cleft rate in mice (A/WySn)
2017, Journal of Cranio-Maxillofacial SurgeryCitation Excerpt :Many studies have suggested that multivitamin supplementation might reduce the occurrence rate of cleft lip/palate (CL/P) (Czeizel, 1993; Botto et al., 2002). It is known that folic acid, as well as B vitamin decreases the number of fetal malformations in humans (Tolarová and Harris, 1995; Gildestad et al., 2015) and animals (Paros and Beck, 1999; Bienengräber et al., 2001; Malek et al., 2003) and is recommended in many countries as standard preventive treatment during pregnancy (US Preventive Services Task Force, 2009). A convincing preventive effect on teratogen-related or sporadic CL/P appearance is discussed controversially (van Rooij et al., 2004; Wilcox et al., 2007; Johnson and Little, 2008; De-Regil et al., 2015; Gildestad et al., 2015; Yang et al., 2016).
Sex distribution is a factor in teratogenically induced clefts and in the anti-teratogenic effect of thiamine in mice, but not in genetically determined cleft appearance
2016, Journal of Cranio-Maxillofacial SurgeryCitation Excerpt :In general, an exogenous stimulus is needed for these conditions to become manifest (Gabka, 1981). Numerous experimental and clinical studies have been performed to investigate reduction of the manifestation rate of these craniofacial malformations by supplementation with B vitamins (Schubert et al., 2002; Schubert and Krost, 2006), multivitamins (Czeizel, 1993; Botto et al., 2002), and/or folic acid (Malek et al., 2003; Bienengräber et al., 2001; Tolarová and Harris, 1995), beginning before fertilization and during the first trimester of pregnancy. Cleft lip with or without cleft palate (CL/P) and cleft palate (CP) have an evident and constant difference in sex ratios in human beings.
Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats
2004, Pathology Research and PracticeThe Soft Tissue Angular Analysis of Facial Profile in Unoperated Adult Patients with Unilateral Cleft Palate
2019, Aesthetic Plastic SurgeryOral cleft prevention program (OCPP)
2012, BMC Pediatrics