KSHV/HHV8-associated lymphoproliferations in the AIDS setting
Section snippets
Association of KSHV/HHV8 with lymphoproliferative disorders in AIDS patients
Kaposi's sarcoma-associated herpesvirus (KSHV) [111] or human herpesvirus 8 (HHV8) is consistently associated with two lymphoproliferative conditions often seen in AIDS patients. It is found in nearly all cases of ‘body cavity-based’ or ‘primary effusion lymphoma’ (BCBL/PEL) and it has been proposed that the presence of HHV8 DNA is a defining feature of this condition. It is also associated with the plasmacytic form of Multicentric Castleman's Disease (MCD), and is found in most cases of MCD in
Phenotypic and molecular characteristics
Primary effusion lymphoma (PEL), also called body cavity-based lymphoma (BCBL), is a rare lymphoma in AIDS patients characterised by its presentation as a malignant effusion in the peritoneal, pleural or pericardial space, most often in the absence of an obvious tumour mass. The lymphoma cells have pleomorphic or anaplastic features combining morphological aspects of large cell immunoblastic and anaplastic large cell lymphomas [6]. They display marked size heterogeneity, irregular and
Multicentric Castleman's disease
Castleman's disease is a localised lymphoproliferative condition, often found in the mediastinum, mesenterial or peripheral lymph nodes and characterised histologically by expanded germinal centres with B cell proliferation and vascular proliferation. Two histological types have been recognised: one, characterised by a pronounced plasma cell proliferation and persistence of the nodal architecture (‘plasma cell variant’), and the other by abnormal germinal centres and abundant hyalinised vessels
Biological and biochemical properties of KSHV viral genes expressed in KSHV-associated lymphoid malignancies in AIDS patients
As reviewed elsewhere 79, 80, several KSHV genes have been implicated in pathogenesis. A comprehensive discussion of their properties would go beyond the scope of this review, and for many of them their expression in lymphoid malignancies is not clear. The following overview is therefore confined to those viral proteins that have been documented to be expressed in PEL or MCD tissues.
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Cited by (47)
HIV-associated lymphomas and gamma-herpesviruses
2009, BloodCitation Excerpt :In most cells, a latent viral gene expression pattern involves the expression of the LANA, a viral D-type cyclin homologue (vcyc), a viral homologue of FLICE inhibitory protein (vFLIP), a pre-miRNA transcript encoding 11 viral miRNAs, as well as vIRF3/K10.5/LANA-2.94-101 In addition, a homologue of IL-6 (vIL-6) is also expressed in some PEL cells.54,102,103 A detailed description of the functional properties of individual KSHV proteins can be found in recent review articles.101,104,105
Epidemiology of HHV-8 infection in HIV-positive patients with and without Kaposi sarcoma: Diagnostic relevance of serology and PCR
2004, Journal of Clinical VirologyNeuropathology of AIDS
2004, AIDS and Other Manifestations of HIV Infection