Editorial: Time is brain!

https://doi.org/10.1016/S1052-3057(10)80125-9Get rights and content

References (24)

  • CM Fisher

    The use of anticoagulants in cerebral thrombosis

    Neurology

    (1958)
  • CM Fisher

    Anticoagulant therapy in cerebral thrombosis and cerebral embolism. A national cooperative study, interim report

    Neurology

    (1961)
  • AB Carter

    Anticoagulant treatment in progressing stroke

    Br Med J

    (1961)
  • JP Whisnant
  • RN Baker et al.

    Anticoagulant therapy in cerebral infarction

    Neurology

    (1962)
  • CH Millikan
  • RJ Fallis et al.

    A double-blind trial of naloxone in the treatment of acute stroke

    Stroke

    (1984)
  • HJ Gelmers

    The effect of nimodipine on the clinical course of patients with acute ischemic stroke

    Acta Neurol Scand

    (1984)
  • HJ Gelmers et al.

    A controlled trial of nimodipine in acute ischemic stroke

    N Engl J Med

    (1988)
  • JR Cutler et al.

    Failure of naloxone to reverse vascular neurologic deficits

    Neurology

    (1983)
  • J Jabaily et al.

    Naloxone administration to patients with acute stroke

    Stroke

    (1984)
  • HP Adams et al.

    A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia

    Stroke

    (1986)
  • Cited by (62)

    • Thrombus composition and thrombolysis resistance in stroke

      2023, Research and Practice in Thrombosis and Haemostasis
    • Language is brain: Improving neurologic health equity for linguistically diverse populations

      2022, Journal of Clinical Neuroscience
      Citation Excerpt :

      All languages share a common neural substrate, the (typically) left perisylvian network. Hence, drawing on the widely known expression “time is brain,” which has been used as a call to action regarding the urgency of stroke care [1,2], we argue that “language is brain,” as well. Despite United States (US) federal regulations mandating non-discrimination on the basis of language [3], communicating with patients who have non-English language preference (NELP) remains an unresolved health equity challenge [4].

    • Posterior Circulation Stroke: Coma (More Than Time) is Brain

      2022, Journal of Stroke and Cerebrovascular Diseases
      Citation Excerpt :

      Indeed, the authors believe that often a low GCS makes endovascular treatment seem more necessary, and our results may very well suggest the contrary – that the presence of coma may weigh against treatment and that these cases warrant strict decision making. The basis for the rationale of “time is brain”22 is the existence of collateral circulation and how distant hemispheric vessels (often leptomeningeal) can compensate a hypoperfused territory.23 On the contrary, the Pcom, regarded as a key element of collateral supply in the posterior circulation,13,24 are relatively close to the basilar artery, and provide means of irrigation to vascular territories that are largely determined by perforating branches.

    • Impact of the SARS-COV-2 Pandemic on the Endovascular Treatment of Acute Stroke – an Italian Single-Center Experience

      2021, Journal of Stroke and Cerebrovascular Diseases
      Citation Excerpt :

      Under the banner of “time is brain”,1 the race towards achieving the fastest treatment in acute stroke is ongoing.

    • Stroke priorities during COVID-19 outbreak: acting both fast and safe

      2020, Journal of Stroke and Cerebrovascular Diseases
      Citation Excerpt :

      Current acute stroke management guidelines recommend designing and implementing public education programs focused on stroke systems, referring acute stroke patients to emergency care and evaluating risk factors for patients presenting with TIA.14 Since AIS is a time-dependent disease and the treatment effectiveness is mainly related to timely access to the therapy,25,26 current guidelines state that emergency therapy should be administrated quickly avoiding unnecessary and potentially time-consuming procedures.14,27 Before COVID-19 outbreak, stroke guidelines have been universally accepted by clinicians involved in acute stroke.14

    View all citing articles on Scopus
    View full text