Original ArticleChanges in aggrecan populations in experimental osteoarthritis*
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Influence of chondrocyte maturation on acute response to impact injury in PEG hydrogels
2012, Journal of BiomechanicsCitation Excerpt :Most notably, there appeared to be an age-dependent shift in the relative amount of ARG-fragment retained in the gel, and that which was released with impact loading. This observation suggests a difference in aggrecan glycosylation, which has been reported to increase during adolescence (Brown et al., 1998), but also increase in cartilage explant injury models (Adams, 1994; Chockalingam et al., 2011; Sui et al., 2009). Collagen II degradation, specifically the C1,2C collagen fragment produced by MMP-1 and MMP-13 (Garvican et al., 2010) is a biomarker of osteoarthritis and is commonly found in the synovial fluid of patients with joint injury (Lohmander et al., 2003; Mohammed et al., 2003).
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2019, InflammopharmacologyChanges in proteoglycan content of articular cartilage during avian degenerative joint disease
2001, Clinical and Experimental RheumatologyA comparison of various 'housekeeping' probes for northern analysis of normal and osteoarthritic articular cartilage RNA
1999, Connective Tissue Research
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Supported by The Medical Research Council of Canada and The Arthritis Society. A preliminary report of this work appeared in J Rheumatol 1987; Supplement 14:107–9, and was presented at the 1992 Annual Meeting of the American College of Rheumatology.