CommentMicroRNA therapeutics in preclinical cancer models
Section snippets
Glossary
- Autochthonous
- A tumour that is formed in the place where it is originally found
- Antagomir
- An oligonucleotide used to silence microRNA
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The let-7 microRNA reduces tumour growth in mouse models of lung cancer
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Cited by (49)
Deciphering the role of KRAS gene in oncogenesis: Focus on signaling pathways, genetic alterations in 3'UTR, KRAS specific miRNAs and therapeutic interventions
2024, Critical Reviews in Oncology/HematologyTargeted delivery of nucleic acids using microfluidic systems
2020, Biomedical Applications of Microfluidic DevicesAn insight of microRNAs performance in carcinogenesis and tumorigenesis; an overview of cancer therapy
2020, Life SciencesCitation Excerpt :Excluding Leukemias in which the malignant cells are easily accessed [4], in solid cancers tissue sampling is achieved by means of biopsy and surgery. Since the procedures are often taken when cancer has considerably developed, such assessments have poor prognostic values [1], Hence, microRNAs closely associated with malignant phenotypes are invaluable diagnostic markers in the initial stages of cancer [1,3–5,29,37,39,40]. Cancer progression can be halted by inhibition of oncogenic microRNAs and/or slicing them with synthetic mRNA-pairing microRNAs, induction of tumor-suppressing microRNAs and reducing microRNA expression through epigenetic manipulations such as promoter methylation.
Animal Models to Study MicroRNA Function
2017, Advances in Cancer ResearchImpact of MicroRNAs in the Cellular Response to Hypoxia
2017, International Review of Cell and Molecular BiologyCitation Excerpt :In particular, a better knowledge of hypoxamiR function in disease conditions for which hypoxia plays a major deleterious role may offer new innovative therapeutic strategies. Indeed, the development of MiRNA-based therapeutics is currently the subject of intensive research efforts especially in lethal and/or chronic diseases (Broderick and Zamore, 2011; Kim et al., 2011b; Pottier et al., 2014; Rupaimoole et al., 2011). MiRNAs have many advantages as a therapeutic modality.