Article
Impact of intracytoplasmic morphologically selected sperm injection on assisted reproduction outcome: a review

https://doi.org/10.1016/S1472-6483(10)60283-0Get rights and content

Abstract

To date, several publications have focused their attention on a new method for observing spermatozoa called ‘motile sperm organelle morphology examination’ (MSOME), which enables the evaluation of the fine nuclear morphology of motile spermatozoa in real time at high magnification (>×6000). As a consequence, a new microinjection procedure called intracytoplasmic morphologically selected sperm injection (IMSI) has been developed. The aim of the present work is therefore to evaluate the efficacy of the IMSI technique in the light of the current literature, focusing attention on the potential clinical application of the selection of strictly morphologically normal spermatozoa in patients undergoing conventional intracytoplasmic sperm injection treatments. In addition, a brief analysis of preliminary data regarding the relationship between IMSI and assisted reproduction treatment outcome is presented.

Section snippets

Marco Nadalini obtained his Biology degree in 2002 at the University of Bologna, Italy. Since then he has been working in the field of assisted reproduction and in 2006 he became a permanent staff member of Tecnobios Procreazione, Centre for Reproductive Health in Bologna. Current research interests include cytogenetic and male infertility, especially regarding molecular biology of the male germ cell and structure of sperm chromatin.

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      Citation Excerpt :

      Several RCT have been performed since the original study. The technique was reviewed and one meta-analysis was published (Nadalini et al., 2009; Setti et al., 2010). The meta-analysis was performed on three of the 35 IMSI studies investigated (Bartoov et al., 2003; Berkovitz et al., 2006; Antinori et al., 2008).

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    Marco Nadalini obtained his Biology degree in 2002 at the University of Bologna, Italy. Since then he has been working in the field of assisted reproduction and in 2006 he became a permanent staff member of Tecnobios Procreazione, Centre for Reproductive Health in Bologna. Current research interests include cytogenetic and male infertility, especially regarding molecular biology of the male germ cell and structure of sperm chromatin.

    Declaration: The authors report no financial or commercial conflicts of interest.

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