ArticleVitrification of human 8-cell embryos, a modified protocol for better pregnancy rates
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GA Rama Raju obtained his medical degree from Andhra Medical College, Visakhapatnam, India, and DNB in obstetrics and gynaecology from NBE, Government of India, New Delhi. Currently he is the director of Krishna IVF Clinic, which is also a nodal centre for laparoscopy training, recognized by the Federation of Obstetric and Gynecological Societies of India. He is named in Who's Who in Medical And Health Care, 2002–2003 and Outstanding Scientists of the 21st Century. He has been visiting faculty
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2019, Best Practice and Research: Clinical Endocrinology and MetabolismCitation Excerpt :Available evidence from published RCTs demonstrate that vitrification (and warming) technique is superior to the slow-freezing method concerning clinical outcomes. Moderate-quality studies clearly show better cryo-survival rates for oocytes, cleavage-stage embryos and blastocysts [57], whereas blastocyst survival rates are significantly increase in embryo cryo-survival following vitrification when compared with slow-freezing (RR = 1.59, 95% CI 1.30–1.93; p < 0.001; I2 = 93%), as shown form pooled data of 3615 embryos (pooled from seven RCTs) [58–64,57]. Furthermore, clinical outcomes were significantly better with cryopreservation of cleavage-stage embryos as compared with slow-freezing, with a higher clinical PR per cycle, (RR = 1.89, 95% CI 1.00–3.59; p = 0.05; I2 = 71.9%) [58,60,64] and a higher LBR per cycle, as published by Debrock et al., (RR = 2.28; 95% CI 1.17–4.44; p = 0.016; 216 cycles) [64,57].
Cryopreservation: Organ preservation
2019, Comprehensive Biotechnology
GA Rama Raju obtained his medical degree from Andhra Medical College, Visakhapatnam, India, and DNB in obstetrics and gynaecology from NBE, Government of India, New Delhi. Currently he is the director of Krishna IVF Clinic, which is also a nodal centre for laparoscopy training, recognized by the Federation of Obstetric and Gynecological Societies of India. He is named in Who's Who in Medical And Health Care, 2002–2003 and Outstanding Scientists of the 21st Century. He has been visiting faculty in obstetrics and gynaecology at Justus Liebig University, Frankfurt, Germany and underwent training in ART in Kiel University, Bielefeld Institute of Reproduction, Germany and in PGD at the Centre for Reproductive Medicine, Dutch-speaking Free University of Brussels. His research interests include reproductive endocrinology, vitrification of gametes and ovarian tissue and PGD.