ArticlesCircadian clockwork genes are expressed in the reproductive tract and conceptus of the early pregnant mouse*
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Martin H Johnson is Professor of Reproductive Sciences in the Department of Anatomy at the University of Cambridge UK, Professorial Fellow of Christ's College Cambridge, and Visiting Professor in the Department of Physiology at the University of Sydney, Australia (1999–2002). He was a member of the Human Fertilisation and Embryology Authority (1993–1999), Chairman of the British Society for Developmental Biology (1984–1989), and Head of the Anatomy Department, Cambridge (1995–1999). He was an
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Human fertility and sleep disturbances: A narrative review
2022, Sleep MedicineCircadian desynchronization in pregnancy of Golden hamster following long time light exposure: Involvement of Akt/FoxO1 pathway
2022, Journal of Photochemistry and Photobiology B: BiologyCitation Excerpt :In various comprehensive studies, the link between clock genes and reproductive health has been testified by localizing their presence in the ovary and uterus [8]. Previous research demonstrated that in females Bmal1 plays a crucial role in secretion of estrogen (E2) and progesterone (P) for the maintenance of female reproductive health and pregnancy [6,9,10]. Previous studies also depicted that dysregulation in circadian clock genes disrupts reproductive functions such as gestation period and time of birth in mammals [11,12].
Circadian clocks, retinogenesis and ocular health in vertebrates: new molecular insights
2022, Developmental BiologyCitation Excerpt :However, when the circadian clock arises during development and how it acts have been long-standing questions (Agrawal et al., 2017; Landgraf et al., 2014; Seron-Ferre et al., 2012; Umemura et al., 2017; Yagita et al., 2010). Clock gene transcripts were repeatedly shown to be maternally inherited but their levels were not rhythmic (Amano et al., 2009; Curran et al., 2008; Dekens and Whitmore, 2008; Hamatani et al., 2004; Johnson et al., 2002). In zebrafish, asynchronous, endogenously-driven cellular oscillations of the zygotic Per1 transcript were shown to start by 1 day post-fertilization (dpf).
Time-Restricted Feeding Regulates Circadian Rhythm of Murine Uterine Clock
2021, Current Developments in NutritionRole of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis
2020, Molecular and Cellular EndocrinologyCitation Excerpt :The fine-tuning of these hormone release patterns combined with optimal tissue sensitivity is obtained through the molecular circadian clock (Fig. 2). This cell-endogenous clock has been linked to every aspect of reproductive physiology including ovarian steroidogenesis, follicular development (Chen et al., 2013a,b), ovulation (Sellix et al., 2010; Mereness et al., 2015), development of the gametes (Johnson et al., 2002; Morse et al., 2003; Amano et al., 2009), fertilization (Johnson et al., 2002), implantation (Greenhill, 2014; Liu et al., 2014; Xu et al., 2016), as well as pregnancy and parturition (Gamble et al., 2013; Miller and Takahashi, 2013). Manipulations (environmental or genetic) that disrupt or alter clock function globally or in specific tissues of the reproductive tract lead to irregular patterns of hormone secretion and infertility (Kennaway, Boden et al., 2012; Mereness et al., 2015).
Martin H Johnson is Professor of Reproductive Sciences in the Department of Anatomy at the University of Cambridge UK, Professorial Fellow of Christ's College Cambridge, and Visiting Professor in the Department of Physiology at the University of Sydney, Australia (1999–2002). He was a member of the Human Fertilisation and Embryology Authority (1993–1999), Chairman of the British Society for Developmental Biology (1984–1989), and Head of the Anatomy Department, Cambridge (1995–1999). He was an invited lecturer at several meetings in the 1990s. In 1989 he was awarded the Albert Brachet Prize and the Diploma of Laureate of the Belgian Royal Academy of Sciences, Letters and Fine Arts, and in 1993 he was appointed Distinguished Visiting Fellow at La Trobe University, Melbourne and was elected to the Society of Scholars of Johns Hopkins University. He is co-author with Professor Barry Everitt of Essential Reproduction, now in its fifth edition from Blackwell Science.
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Paper based on contribution presented at the Alpha meeting in New York, USA, September 2001.