Elsevier

The Surgeon

Volume 4, Issue 6, December 2006, Pages 378-383
The Surgeon

Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour

https://doi.org/10.1016/S1479-666X(06)80114-9Get rights and content

Background: The Buschke-Löwenstein tumour (BLT) or giant condyloma acuminata is a rare disease which affects the anogenital region. Although histologically benign, it behaves in a malignant fashion, infiltrating the surrounding tissues. The morbidity and mortality from this tumour is high, as is the risk of recurrence following treatment. It lies on the continuum between the benign condylomata acuminata and squamous cell carcinoma. The human papillomavirus is implicated in its aetiology. Treatment is controversial, with topical chemotherapy, radiotherapy, immunotherapy and radical surgery all having been employed. Chemoradiation remains the mainstay of treatment for anal cancers but has not been routinely employed in the management of the BLT without squamous cell carcinoma transformation. Methods: Two cases of extensive perineal BLT treated with chemoradiation and subsequent surgical excision are presented. Results: The f rst patient had a good symptomatic response to the chemo-radiation but unfortunately died of recurrent disease following surgery. The second patient had a macroscopically complete response to chemoradiation and remains well following abdominoperineal excision. Conclusion: Pre-operative chemoradiation has proved to be useful in management for histologically proven benign BLT

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