Original Article/BiliaryExpression of HBx protein in hepatitis B virus-infected intrahepatic cholangiocarcinoma
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Cited by (20)
The emerging role for Cullin 4 family of E3 ligases in tumorigenesis
2019, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :Transgenic overexpression of Hbx induces liver carcinogenesis in rodent models [129,130], which is also found to be upregulated in human liver cancer specimens [131]. Increased HBx expression is also observed in intrahepatic cholangiocarcinoma [132] and adenoid cystic carcinoma [133], suggesting a general involvement of HBx in promoting tumorigenesis. Mechanistically, apart from its involvement in HBV replication, SMC5/6 also has a vital role in regulating cell division and proliferation while HBx could interact with apoptotic machinery to stimulate downstream oncogenes [134,135], which together explain the oncogenic impact of HBx in human cancers (Tables 3 and 5).
Is Hepatitis B Virus–Associated Intrahepatic Cholangiocarcinoma Preventable With Antiviral Treatment?
2018, Clinical Gastroenterology and HepatologyEffect of Nucleos(t)ide Analogue Therapy on Risk of Intrahepatic Cholangiocarcinoma in Patients With Chronic Hepatitis B
2018, Clinical Gastroenterology and HepatologyCitation Excerpt :Although HBV can be found in bile duct epithelial cells and tumor tissues of CCA,12,13,24 the precise pathogenic mechanisms of HBV-mediated CCA remain largely unclear.14 In previous pathologic studies for HBV-related CCA, the detection rate of hepatitis B virus X protein could be as high as 60%–70%.24,25 In a zebrafish model, liver fibrosis and ICC were induced by dual expression of hepatitis B virus X and hepatitis C virus core protein, and the signaling pathway of transforming growth factor beta 1 was involved.26
Antiviral therapy improves survival in patients with HBV infection and intrahepatic cholangiocarcinoma undergoing liver resection
2018, Journal of HepatologyCitation Excerpt :It is possible that HBV x protein (HBx) acts as a trans-activating protein by binding to nuclear transcription factors to stimulate the intracellular signaling pathways that promote tumor cell growth.11 HBV infection may also induce liver progenitor cell activation, which when accompanied by abnormal genetic changes caused by HBx activation, contributes to malignant transformation.12 The association between HBV infection and outcomes after surgical and systemic treatments has been reported in HBV-infected patients with HCC or other malignancies.13–16
Hepatitis B and Risk of Non–Hepatocellular Carcinoma Malignancy
2016, Clinics in Liver DiseaseCitation Excerpt :Similarly, a common pathway of inflammation, cirrhosis, and carcinogenesis has been proposed because of evidence of greater inflammation and scarring in HBV ICC versus non–-HBV-related ICC.27 In addition, similar to HCC, the HBx and p53 proteins have been shown to be present in liver tissue surrounding resected ICC.28 The association between chronic hepatitis B and extrahepatic malignancy, particularly NHL, warrants further study to define the possible pathogenic mechanisms.
Clinical presentation, risk factors and staging systems of cholangiocarcinoma
2015, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :In patients with bile-duct cysts the incidence of CCA in the first decade of their life and the risk of malignancy decreases after cyst excision [41,42,44–46]. Other confirmed risk factors are virus infection with hepatitis B (HBV) and hepatitis C (HCV) [47–54]. However, the contribution of hepatitis infection differs between Western countries and Asia, where HBV is endemic.