Review ArticlePathogenesis and treatment of parenteral nutrition-associated liver disease
References (85)
- et al.
Phytosterolemia in parenteral nutrition patients: implications for liver disease development
Nutrition
(2008) - et al.
High serum phytosterol levels in short bowel patients on parenteral nutrition support
Clin Nutr
(2005) - et al.
The prevention and treatment of intestinal failure-associated liver disease in neonates and children
Surg Clin North Am
(2011) - et al.
Total parenteral nutrition therapy and liver injury: a histopathologic study with clinical correlation
Hum Pathol
(2012) - et al.
Does total parenteral nutrition induce gallbladder sludge formation and lithiasis?
Gastroenterology
(1983) Intestinal failure-associated liver disease: what do we know today?
Gastroenterology
(2006)- et al.
L-cysteine and glutathione metabolism are impaired in premature infants due to cystathionase deficiency
Am J Clin Nutr
(1995) - et al.
Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model
J Pediatr Surg
(2011) - et al.
The route of lipid administration affects parenteral nutrition-induced hepatic steatosis in a mouse model
J Pediatr Surg
(2005) - et al.
Immune modulation by parenteral lipid emulsions
Am J Clin Nutr
(2007)
Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease
Gastroenterology
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
Cell
Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
Arch Biochem Biophys
Liver phospholipidosis induced by parenteral nutrition: histologic, histochemical, and ultrastructural investigations
Gastroenterology
Essential fatty acid deficiency in four adult patients during total parenteral nutrition
Am J Clin Nutr
The effect of short-term total parenteral nutrition on hepatic function in the human neonate: a prospective randomized study demonstrating alteration of hepatic canalicular function
J Pediatr
Low plasma free choline is prevalent in patients receiving long term parenteral nutrition and is associated with hepatic aminotransferase abnormalities
Clin Nutr
Plasma concentrations of transsulfuration pathway products during nasoenteral and intravenous hyperalimentation of malnourished patients
Am J Clin Nutr
Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation
Hepatology
Intestinal permeability and bacterial translocation are uncoupled after small bowel resection
J Pediatr Surg
New approaches to understanding the etiology and treatment of total parenteral nutrition-associated cholestasis
Semin Pediatr Surg
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
Hepatology
Effect of total parenteral nutrition on gut hormone release in humans
Gastroenterology
Protective effect of probiotics on intestinal barrier function in malnourished rats after liver transplantation
Hepatobiliary Pancreat Dis Int
Ursodeoxycholic acid for treatment of cholestasis in children on long-term total parenteral nutrition: a pilot study
Gastroenterology
Preventing parenteral nutrition liver disease
Early Hum Dev
Fish oil-based emulsion for the treatment of parenteral nutrition associated liver disease in an adult patient
e-SPEN Eur E J Clin Nutr Metab
Effect of omega-3 polyunsaturated fatty acids to reverse biopsy-proven parenteral nutrition-associated liver disease in adults
Clin Nutr
Parenteral fish-oil-based lipid emulsion improves fatty acid profiles and lipids in parenteral nutrition-dependent children
Am J Clin Nutr
Protective effect of parenteral glutamine supplementation on hepatic function in very low birth weight infants
Clin Nutr
Glutamine attenuates TPN-associated liver injury in infant rabbits
Eur J Pediatr
Relationship between biopsy-proven parenteralnutrition-associated liver fibrosis and biochemical cholestasis in children with short bowel syndrome
J Pediatr Surg
Recovery from liver dysfunction after adult isolated intestinal transplantation without liver grafting
Transplant Proc
Effect of parenteral serum plant sterols on liver enzymes and cholesterol metabolism in a patient with short bowel syndrome
Nutr Clin Pract
Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR
Pediatr Res
Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis
Nat Clin Pract Gastroenterol Hepatol
Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation
Hepatology
Parenteral nutrition-associated liver disease in adult and pediatric patients
Nutr Clin Pract
Some new insights in intestinal failure-associated liver disease
Curr Opin Organ Transplant
Recent advances in the management of intestinal failure-associated liver disease
Curr Opin Clin Nutr Metab Care
Pediatric parenteral nutrition: putting the microscope on macronutrients and micronutrients
Nutr Clin Pract
Risk factors for parenteral nutrition–associated liver disease following surgical therapy for necrotizing enterocolitis: A Glaser Pediatric Research Network Study
J Pediatr Gastroenterol Nutr
Cited by (80)
A risk model for parenteral nutrition-associated liver disease in patients with severe acute pancreatitis
2024, Arab Journal of GastroenterologyNutritional Considerations in the Hospital Setting
2021, Gastroenterology Clinics of North AmericaCitation Excerpt :For those unable to meet these goals spontaneously, EN is favored over PN because it helps to maintain gut integrity, which has possible implications in pathogenesis of alcoholic hepatitis.49 PN should generally be avoided in these patients given its inherent risks as well as its pathogenesis in liver disease.50 Other key practical nutritional measures for hospitalized patients with alcoholic hepatitis are to address common vitamin and micronutrient deficiencies (especially B vitamins, thiamine, and zinc), avoid prolonged periods of fasting and foods that make early satiety worse (high fiber), provide frequent snacks, especially at night time and in morning (to decrease gluconeogenesis/breakdown of protein), and consider feeding tubes in those unable to eat on their own violation.44
Intestinal failure–associated liver disease: Current challenges in screening, diagnosis, and parenteral nutrition considerations
2024, Nutrition in Clinical Practice