Regular ArticleGenetic aspects of ankylosing spondylitis
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Cited by (97)
Microbes, helminths, and rheumatic diseases
2020, Best Practice and Research: Clinical RheumatologyDiagnostic contribution of HLA-A, B, C, DR genotyping in inflammatory joint disease
2018, Revue du Rhumatisme (Edition Francaise)Contribution of ancient human remains analysis to the understanding of the variability in HLA-B gene variants in relation to the diagnosis of spondyloarthropathies
2018, Journal of AutoimmunityCitation Excerpt :In the DNAzol method, the sample is incubated and stirred for 3 days in the dark with DNAzol, which contains guanidine thiocyanate (GuSCN) and the supernatant obtained is concentrated and purified using purification columns with silica base (PCR Purification Kit by QIAgen) [25,26]. The HLA-B gene shows a high degree of genetic polymorphism, mainly located in exons 2 and 3 of its eight exons [27–29]. There are hundreds of HLA-B alleles, defined according to the differences in the nucleotide sequence [29,30].
Diagnostic contribution of HLA-A,B,C,DR genotyping in inflammatory joint disease
2018, Joint Bone SpineHLA-B*27 subtypes and their implications in the pathogenesis of ankylosing spondylitis
2018, GeneCitation Excerpt :In addition, HLA-B*27:05:02 is identical with HLA-B*27:13, except in the gene leader segment, which is not expressed on the cell surface. Therefore, both alleles of HLA-B*27:05:02 and HLA-B*27:13, encode the same HLA-B*27 molecule (Khan and Ball, 2002). HLA-B*27:06, which has no association with AS, varies from HLA-B*27:04 by only two amino acids substitution, including residues of position 114 (His to Asp) and position 116 (Asp to Tyr).