Original articlesBiomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease
Section snippets
Study population
Patients with available serum levels and a consistent liver biopsy examination were included. These patients were included prospectively in a cohort of alcoholic patients for which one primary end point was the identification of biochemical markers. 11, 13, 34, 35 All patients had a self-reported daily alcohol consumption equivalent to at least 50 g of pure ethanol during the preceding year, with a mean of 146 g/day (SE, 80 g/day) for 17 (SE, 10) years. Information of alcohol consumption was
Patients
The 221 included patients were not different from the 71 patients who were not included (Table 1). The majority (93%) had some degree of fibrosis, 31% had cirrhosis, and 29% had alcoholic hepatitis. The mean interval between the serum sample for biochemical markers and the liver biopsy was 1 day (mean), 8 the median 9 days, and range of 31 days before to 6 days after. All patients included were actively drinking in the period prior to admission. The cause of admission was alcoholism without
Discussion
Our results show that for the assessment of fibrosis, FT has high predictive values for the diagnosis of clinically significant lesions in chronic alcoholic liver disease.
Our study has several limitations that must be acknowledged. First, despite the use of a prospective cohort and the prospective assessment of 5 FT components, the haptoglobin level assessment was made retrospectively. Nevertheless, the analyses of histologic specimens and biochemical markers were performed blindly, and the
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Supported by grants from the Association pour la Recherche sur le Cancer and the Association de Recherche sur les Maladies Virales Hépatiques (to T.P.). T.P. is a consultant for and owns shares in Biopredictive, the company marketing FibroTest-ActiTest.