Anti-inflammatory effects of enteral diet components on Crohn's disease-affected tissues in vitro☆
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2019, Dietary Interventions in Gastrointestinal Diseases: Foods, Nutrients, and Dietary SupplementsAdvancing nutritional therapy: A novel polymeric formulation attenuates intestinal inflammation in a murine colitis model and suppresses pro-inflammatory cytokine production in ex-vivo cultured inflamed colonic biopsies
2017, Clinical NutritionCitation Excerpt :However, this evidence is derived from intestinal epithelial cells experiments [19]. Furthermore, studies that did involve organ culture of colonic biopsies from CD patients, did not include key pro-inflammatory mediators including TNF-α and IL-6 in their investigations [25]. TNF-α, IL-8 and IL-6 are considered master pro-inflammatory mediators serving vital functions in IBD pathogenesis [26], and are derived from mononuclear cells of the lamina propria, most notably from macrophages [15,27].
Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; In vitro and in vivo studies
2016, International ImmunopharmacologyCitation Excerpt :Growing evidence suggests that dietary fats influence intestinal inflammation and regulate mucosal immunity. Epidemiological and animal studies have been emphasized that dietary intake of dietary long-chain n-3 PUFA associated with a reduced risk of colitis [2–5]. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the two major long-chain n-3 PUFAs of fish oil, incorporates in plasma and cellular phospholipid pool at the expense of arachidonic acid (ARA) [6].
Efficacy of an elemental diet in achieving clinical remission in dogs with chronic enteropathy
2023, Journal of Veterinary Internal MedicineReview article: Mechanisms underlying the effectiveness of exclusive enteral nutrition in Crohn's disease
2023, Alimentary Pharmacology and Therapeutics
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Part of study was presented at British Society of Gastroenterology Annual Conference, Birmingham 2000 (Gut 2000A61Supp111): W42).