Document heading
Evaluation of antioxidant and anti-inflammatory activity of Euphorbia heyneana Spreng

https://doi.org/10.1016/S2221-1691(11)60154-8Get rights and content

Abstract

Objective

To assess the antioxidant and anti-inflammatory activities of the alcoholic extract of Euphorbia heyneana (E. heyneana) in carrageenan induced inflammation in rats.

Methods

In vitro antioxidant activity was evaluated for superoxide radical, hydroxyl radical and DPPH radical scavenging activity. Three doses 200, 400 and 800 mg/kg were tested for anti-inflammatory activity in carrageenan induced rat paw oedema model and paw thickness was measured every one hour up to 6 hours.

Results

The alcoholic extract of E. heyneana produced dose dependent inhibition of superoxide radical, hydroxyl radical and DPPH radicals. In carrageenan induced inflammation model, all three doses produced significant percentage inhibition of rat paw oedema and 800 mg/kg dose produced maximum percent inhibition of rat paw oedema (47.06%) among the three doses compared to control group.

Conclusions

It can be concluded that alcoholic extract of E. heyneana shows good in vitro antioxidant and in-vivo anti-inflammatory activities in rats.

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    Available online 15 October 2011

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