Original investigationsProton magnetic resonance spectroscopy of brain tumors correlated with pathology1
Section snippets
Subjects
This study consisted of 27 patients:, 10 females and 17 males ages 22–83 years (average 43.8). All 27 patients presented with central nervous system symptoms and were assessed with brain MRI that demonstrated a suspicious brain tumor. Because of the brain lesion, the 27 patients were evaluated with 1H-MRS to confirm tumor diagnosis; in the case of astrocytomas, an attempt was made to grade the tumor. Lesions suspected of being tumors in 25 patients were then stereotactically biopsied. Twenty
Results
MRI and 1H-MRS was obtained in 27 patients and pathology examination was obtained in 25 patients. Seventeen of the 25 patients biopsied with astrocytoma were classified by WHO criteria: 9 patients with Grade 4 tumors, 3 patients with Grade 3 tumors, 3 patients with Grade 2 tumors, and 1 patient with Grade 1 tumor. The remaining nine patients with lesions were: one patient with medulloblastoma, two patients with adenocarcinomas, two patients with abnormal spectra but without malignancy, one
Discussion
1H-MRS is a noninvasive technique for detecting the presence of cancerous tissue in the brain through its metabolic activity. 1H-MRS has an important role in clinical neuro-oncologic management. It has the potential for accurate diagnosis without surgical tissue sampling, to be an adjunct to imaging for planning neurosurgical procedures to enhance probability of representative biopsy and maximizing cytoreduction, to monitor treatment success, and to differentiate radioactive injury from
Acknowledgment
The authors thank Ron Thomas, PhD, for the statistics.
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Cited by (0)
W.G. received funding in the radiology summer externship program from the Department of Radiology and the School of Medicine of Wayne State University.