Original InvestigationDetection of Occult Foci of Breast Cancer Using Breast-Specific Gamma Imaging in Women with One Mammographic or Clinically Suspicious Breast Lesion
Section snippets
Subjects
A retrospective review was performed of the records of all patients who underwent BSGI from January 1, 2004, through June 4, 2007. Among these, 159 women met the following criteria: (1) one suspicious breast lesion was found on physical exam and/or mammography, (2) BSGI was performed to evaluate for occult cancerous lesions in the breasts, and (3) the patient was proven by pathology to have one or more foci of breast cancer. Institutional review board approval and Health Insurance Portability
Baseline Characteristics
One hundred fifty-nine women with one suspicious lesion on physical exam or mammography who underwent BSGI were included. Sixty-two of the women (39%) were premenopausal and 97 (61%) were postmenopausal. Nineteen of these women (12%) had personal histories of breast cancer. Family histories of breast cancer were present in 68 women (43%), of whom 35 women had family histories of breast cancer in first-degree relatives. One woman was adopted, and her family history was unknown.
The Breast Imaging
Discussion
The detection of multifocal, multicentric, and bilateral breast cancer is important because it alters the surgical management of the patient (28). The identification of all foci of breast cancer is a critical component of optimal patient care. BSGI is a novel, physiologically based adjunct imaging modality for the diagnosis of breast cancer that is increasingly being used. BSGI has been shown to reliably detect breast cancers, including subcentimeter cancers, as well as difficult-to-detect
References (32)
- et al.
Evaluation of a high-resolution, breast-specific, small-field-of-view gamma camera for the detection of breast cancer
Nucl Instrum Methods Phys Res A
(2003) - et al.
Detection of ductal carcinoma in situ with mammography, breast specific gamma imaging, and magnetic resonance imaging: a comparative study
Acad Radiol
(2007) - et al.
Imaging breast cancer
Radiol Clin N Am
(2007) - et al.
Bilateral synchronous breast cancer: mode of detection and comparison of histologic features between the 2 breasts
Surgery
(2000) - et al.
Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer
N Engl J Med
(1989) - et al.
Institut Gustave-Roussy Breast Cancer Group. Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data
J Clin Oncol
(1996) - et al.
Standards for breast-conservation treatment
CA Cancer J Clin
(1992) - et al.
Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery
Cancer
(1985) Multicentricity of breast carcinoma demonstrated by routine correlated serial subgross and radiographic examination
Cancer
(1977)- et al.
Multicentricity of non-palpable breast cancer
Cancer
(1980)
Multicentric breast carcinomas: clinical-radiographic-pathologic whole organ studies and 10-year survival
Cancer
Multicentricity in breast cancer: a study of 366 cases
Am J Clin Pathol
Multicentricity in breast cancer: whole-organ analysis and clinical implications
Br J Cancer
Diagnosis of breast cancer: contribution of US as an adjunct to mammography
Radiology
ACR practice guideline for the performance of a breast ultrasound examination
Sydney breast imaging accuracy study: comparative study of mammography and sonography in young women with symptoms
AJR Am J Roentgenol
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