Nanotechnology approaches for personalized treatment of multidrug resistant cancers☆
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Graphical abstract
Abbreviations
ABC
adenosine triphosphate (ATP)-binding cassette
ASO
antisense oligonucleotides
CPT
camptothecin
DBD
drug-binding domain
DDS
drug delivery system
DOX
doxorubicin
EPR
enhanced permeability and retention effect
IC50 dose
a dose that kills 50% of cells
LHRH
luteinizing hormone-release hormone
NBD
nucleotide-binding domain
NLC
nanostructured lipid carriers
PAMAM
poly(amido amine)
siRNA
small interfering RNA
SNP
single-nucleotide polymorphism
TMD
transmembrane domain
TPADDS
targeted proapoptotic drug delivery system
Keywords
Passive and active targeting
Drug delivery system
Pump and nonpump resistance
Antibody
siRNA
Antisense oligonucleotides
Peptides
Cancer stem cells
LHRH
CD44
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This review is part of the Advanced Drug Delivery Reviews theme issue on “Nanotechnology and drug resistance”.
Copyright © 2013 The Authors. Published by Elsevier B.V.