Clinical InvestigationHypertensionNatural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: A double-blind, placebo-controlled pilot study
Section snippets
Study population
Forty patients with grade-1 HT, aged 30 to 70 years, were recruited from primary care clinics and through advertisements published in the local newspapers. Grade-1 HT was defined as SBP between 140 and 159 mm Hg, diastolic blood pressure (DBP) between 90 and 99 mm Hg, or both, measured with the subject in the sitting position in at least 3 different occasions. Subjects treated for HT or dyslipidemia, who had any suspected allergy to tomato, carotenoids, or α-tocopherol, or taking vitamins and
Participants
Recruitment and allocation took place between March to August 2001. Thirty-four participants were included in the trial of whom 31 (91.1%) completed all study phases: 18 men and 13 women with a mean age of 48 (range 30-73) years. Three participants (8.9%) dropped out because of lack of compliance (n = 1) and complaints of dizziness (n = 1) and unspecific rash (n = 1), both during the first placebo period. Mean BMI remained constant during the course of the study (29.5 ± 4.3 at baseline and 29.2
Discussion
In this study, short-term, daily oral supplementation of carotenoid-rich tomato extract significantly decreased SBP and DBP and reduced levels of lipid peroxidation products. We particularly selected nonsmoking, recently diagnosed patients with grade-1 HT, receiving no antihypertensive or lipid-lowering pharmaceutical therapy, without significant cardiovascular risk factors other than HT. Patients who reported taking vitamins and other food additives were excluded from the trial, avoiding the
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