Original articleRetinal Fluorescein, Indocyanine Green Angiography, and Optic Coherence Tomography in Non-Hodgkin Primary Intraocular Lymphoma
Section snippets
Patients and Methods
This is a comparative, retrospective, interventional case series. Each patient signed a consent form prior to surgery. We reviewed all patients who underwent vitreous sampling for cytological analyses over a 70-month period between January 1, 1999 and November 18, 2005.
Prior to tissue diagnosis, we assessed clinical characteristics, including best-corrected visual acuity and inflammation of the anterior segment that was objectively quantified by the Laser Cell Flare Meter (Kowa FC 1000, Tokyo,
Results
Over the 70-month period, cytological analysis was performed on 256 specimens of vitreous from 244 patients. Twelve patients had 2 vitreous samplings. Women constituted 56% of the patients, and the mean age was 56.3 ± 17.6 years old.
We performed 17 vitrectomies in patients with acute infections including 7 patients with acute endophthalmitis and10 with systemic candida. There were 14 patients with chronic infections, and vitrectomies showed 7 with Toxoplasma gondii, 4 with Toxocara, 2 with
Discussion
A previous study reported that FA in intraocular NHL showed the presence of disturbances in the RPE.3 These disturbances were described as blockages and late staining. In our current work, the clusters of small hypofluorescent lesions were well-defined in the early phase and remained hypofluorescent in the late phase, indicating a masking effect of the choroidal fluorescence. This pattern was present in 45% of the intraocular NHL cases, compared with 2% of the nonintraocular NHL cases. The
Dr Christine Fardeau, has acquired the specialization in Ophthalmology in 1991 and has been a fellow from 1990 to 1993. She has obtained a diploma of Applied Statistics from Medicine Paris XI and a masters of Cell Biology. Dr Fardeau is formerly a Hospital physician and Chief Consultant from 1994 at the Department of Ophthalmology lead by Prof P. LeHoang in Pitié-Salpétrière Hospital, where she currently has managed medical and surgical treatment in uveitis patients. Dr Fardeau has written
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Dr Christine Fardeau, has acquired the specialization in Ophthalmology in 1991 and has been a fellow from 1990 to 1993. She has obtained a diploma of Applied Statistics from Medicine Paris XI and a masters of Cell Biology. Dr Fardeau is formerly a Hospital physician and Chief Consultant from 1994 at the Department of Ophthalmology lead by Prof P. LeHoang in Pitié-Salpétrière Hospital, where she currently has managed medical and surgical treatment in uveitis patients. Dr Fardeau has written several publications and belongs to several scientific associations such as the Association for Research in Vision and Ophthalmology and the International Uveitis Study Group. Dr Fardeau paraprofessional experiences have included voluntary ophthalmological service in various associations in Columbia and in France.
See accompanying Editorial on page 764.