Original articleAssociation between Foveal Photoreceptor Integrity and Visual Outcome in Neovascular Age-related Macular Degeneration
Section snippets
Patient Population
We retrospectively reviewed the medical records of 51 eyes of 51 consecutive patients with subfoveal neovascular AMD who were treated successfully with PDT and who were followed-up for more than 24 months after the initial treatment. At the initial visit, all patients showed subfoveal exudative changes, including serous retinal detachment (RD) or macular edema. At the final visit, all eyes were examined with SD-OCT to confirm resolution of the exudative changes. Those eyes with a foveal
Results
Before treatment, all studied eyes showed serous RD or retinal edema beneath the fovea resulting from the subfoveal CNV associated with AMD. Treatment with PDT resolved these exudative changes. At the final visit, mean foveal RT ± SD was reduced to 153.6 ± 60.0 μm. Mean VA ± SD was maintained successfully with PDT, being 0.55 ± 0.33 logMAR units before treatment and 0.64 ± 0.42 logMAR units at the final visit (P = .14). Despite the reduced foveal thickness, however, some eyes showed a poor
Discussion
The present study of 51 eyes with AMD showed that VA after successful treatment by PDT is correlated significantly with OCT findings on the status of the IS/OS, rather than with the foveal RT. Final VA was better in those eyes in which the IS/OS line was detected beneath the fovea. When eyes with AMD are treated successfully with PDT and when the exudative change has resolved, the condition of the outer segment of the foveal photoreceptor layer is involved in visual outcome.
Although many
Hisako Hayashi, MD, graduated from Hiroshima University Medical School, and obtained her MD in 2003. She completed the residency program at Kyoto University Hospital, Kyoto, Japan. Dr Hayashi is pursuing her PhD degree in the application of genomics for ophthalmology at the Department of Ophthalmology at Kyoto University Graduate School of Medicine. Dr Hayashi's interest includes the genomics for multifactorial ocular diseases including macular diseases.
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Hisako Hayashi, MD, graduated from Hiroshima University Medical School, and obtained her MD in 2003. She completed the residency program at Kyoto University Hospital, Kyoto, Japan. Dr Hayashi is pursuing her PhD degree in the application of genomics for ophthalmology at the Department of Ophthalmology at Kyoto University Graduate School of Medicine. Dr Hayashi's interest includes the genomics for multifactorial ocular diseases including macular diseases.