Original articleRetinal Pseudocysts in Age-Related Geographic Atrophy
Section snippets
Methods
At the Centre Ophtalmologique d'Imagerie et de Laser, a private-practice tertiary care retinal center in Paris, France, the charts and images of 68 consecutive patients with a diagnosis of GA in at least 1 eye were retrospectively reviewed over a period of 3 months.
Inclusion criteria were dry age-related macular degeneration with GA of at least half a disk area, imaged both by color fundus photography and SD-OCT. Some patients had also been imaged by fundus autofluorescence and fluorescein
Results
Eighty-eight eyes of 68 patients were included. Patients comprised 50 women (73%) and 18 men. They were aged from 61 to 94 years (mean age: 79.8 ± 7.9). Twenty patients had bilateral GA. The right eye was studied in 50 cases, and the left eye in 38.
Twenty-four of the 88 eyes (27.2%) exhibited pseudocysts corresponding to cystoid spaces (FIGURE 1, FIGURE 2, FIGURE 3). The 95% confidence interval for the prevalence estimate for pseudocysts is [17.72%–36.28%]. The pseudocysts were located just
Discussion
The present study reports the presence of pseudocysts in a subset of eyes presenting with typical GA. Pseudocysts were identified thanks to meticulous analysis of the defilade of the entire recorded square of the SD-OCT scans of the 88 eyes with GA, and were found in 24 eyes (27.2%). Recognition of pseudocysts may be of great importance, because numerous clinical studies now in progress are being performed to test potential therapies for dry AMD and are using OCT to monitor the course of
Salomon Y. Cohen received his MD from Paris University in 1990. He performed most of his ophthalmology residency in departments specialized in Retina, and his fellowship at the Creteil University Eye Clinic, chaired by Professor Gabriel J. Coscas. He has completed a PhD in Neurosciences, and is currently practicing as Retina specialist in private practice and at Hospital Lariboisière, Paris, in Professor Alain Gaudric's department. He has authored five books devoted to fluorescein angiography,
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Salomon Y. Cohen received his MD from Paris University in 1990. He performed most of his ophthalmology residency in departments specialized in Retina, and his fellowship at the Creteil University Eye Clinic, chaired by Professor Gabriel J. Coscas. He has completed a PhD in Neurosciences, and is currently practicing as Retina specialist in private practice and at Hospital Lariboisière, Paris, in Professor Alain Gaudric's department. He has authored five books devoted to fluorescein angiography, indocyanine green angiography, ageing eye, age-related macular degeneration, and low vision rehabilitation. He has also authored more than 70 papers, most of them in peer-reviewed international journals. He is recipient of the American Academy of Ophthalmology Achievement Award.