Original articleVitreous Levels of Angiopoietin-1 and Angiopoietin-2 in Eyes With Retinopathy of Prematurity
Section snippets
Methods
Forty-eight eyes of 36 infants (17 female and 19 male infants) with stage 4 ROP (4A, 36 eyes; 4B, 12 eyes) were studied. The mean gestational age of the infants was 24.2 weeks (range, 22–26 weeks), and the mean birth weight was 640 grams (range, 332–977 grams). All of the infants underwent primary vitreous surgery at the Osaka University Hospital, Osaka, Japan from July 5, 2007 through December 24, 2009. All of the eyes underwent indirect photocoagulation of the avascular peripheral retina
Results
Among the eyes with stage 4 ROP, 22 eyes were classified as highly vascular-active ROP, 15 eyes as moderately vascular-active ROP, and 11 eyes as mildly vascular-active ROP. The mean vitreous level of Ang-1 was 201.9 pg/mL (range, 0 to 461.7 pg/mL) in the highly vascular-active ROP eyes, 216.1 pg/mL (range, 8.5 to 637.0 pg/mL) in the moderately vascular-active ROP eyes, 533.8 pg/mL (range, 218.9 to 1044.9 pg/mL) in the mildly vascular-active ROP eyes, and 0 pg/mL (range, 0 to 0 pg/mL) in the
Discussion
The major findings in this study are: first, the vitreous level of Ang-1 was significantly higher in the highly, moderately, and mildly vascular-active ROP eyes than in control eyes. Second, the vitreous Ang-2 level was significantly higher in the highly and moderately vascular-active ROP eyes than in control eyes. And third, there was a significant negative correlation between the Ang-1 and Ang-2 levels in the vitreous fluid of the moderately and mildly vascular-active ROP eyes.
Ang-1 was first
Tatsuhiko Sato, MD, received his medical degree from Osaka University Graduate School of Medicine, Suita, Japan, in 2001. He completed residency at Osaka University Hospital. Now he is an attending staff in Ophthalmology at Osaka Rosai Hospital. His field of interest includes surgical treatment of vitreoretinal disease such as diabetic retinopathy, retinal detachment, and retinopathy of prematurity.
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2018, Progress in Retinal and Eye ResearchCitation Excerpt :Of these, in terms of retinal vascular development, the most important is VEGF. HIF-1α is also the master transcriptional regulator at a cellular level for numerous other genes that have a role in ROP, including erythropoitein (EPO) (Smith, 2008), angiopoietin 1 & 2 (Sato et al., 2011) and platelet-derived growth factor subunit B (PDGFB) (Wilkinson-Berka et al., 2004). Conversely, the presence of the mainly placental derived growth factor, insulin-like growth factor 1 (IGF-1), is essential for the regulation of HIF-1α protein synthesis; removing the neonate from the intrauterine environment can have potentially serious effects on HIF-1α expression, fetal development as a whole, and ultimately, normal retinal vascular development (Smith, 2008).
Tatsuhiko Sato, MD, received his medical degree from Osaka University Graduate School of Medicine, Suita, Japan, in 2001. He completed residency at Osaka University Hospital. Now he is an attending staff in Ophthalmology at Osaka Rosai Hospital. His field of interest includes surgical treatment of vitreoretinal disease such as diabetic retinopathy, retinal detachment, and retinopathy of prematurity.