Original articleFoveal Cone Outer Segment Tips Line and Disruption Artifacts in Spectral-Domain Optical Coherence Tomographic Images of Normal Eyes
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Patients and Methods
Forty-six eyes of 46 healthy volunteers (19 men and 27 women) without any eye diseases were studied. The right eye of each subject was chosen arbitrarily to study. Each subject had a routine eye examination including measurements of the best-corrected visual acuity (BCVA) and intraocular pressure. All of the subjects had a BCVA of ≥20/20.
SD-OCT images were obtained by 6-mm scans with the Cirrus HD-OCT instrument (OCT 4000, Carl Zeiss Meditec, Dublin, California, USA) with both the standard
Results
The mean age of the subjects was 33.0 years with a range from 23 to 50 years. The mean decimal BCVA was 1.1 with a range from 1.0 to 1.5. The mean refractive error was −1.49 diopters (D) with a range from −8.0 to +3.25 D. The intraocular pressure ranged from 12 to 18 mm Hg. The mean signal strengths were 8.2 (horizontal standard scan), 8.3 (vertical standard scan), 8.3 (horizontal HD scan), and 8.3 (vertical HD scan); the range of signal strength was from 6 to 10.
In the SD-OCT images, the COST
Discussion
The correlations between the visual acuity and the integrity of the foveal COST line detected by commercial SD-OCT instruments has been reported to be significant in cases of occult macular dystrophy,16, 18 adult-onset foveomacular vitelliform dystrophy,17 macular hole,19 and central serous chorioretinopathy.20 Morphologic changes including an absence of the foveal COST line in the SD-OCT images have been reported to be correlated with the condition of the retina in eyes with retinal diseases.16
Tosho Rii a.k.a. Tong-Sheng Lee, MD, is currently an Instructor of Ophthalmology, Kyorin University Medical School, Tokyo, Japan. He received his MD from China Medical University, Taiwan, in 1997 and completed his ophthalmology residency at Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. He gained laboratory research experiences in Taipei Medical University and Osaka University, and then joined the vitreo-retinal services of the Kyorin Eye Center in 2010. Dr Rii's research interest is in
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Tosho Rii a.k.a. Tong-Sheng Lee, MD, is currently an Instructor of Ophthalmology, Kyorin University Medical School, Tokyo, Japan. He received his MD from China Medical University, Taiwan, in 1997 and completed his ophthalmology residency at Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. He gained laboratory research experiences in Taipei Medical University and Osaka University, and then joined the vitreo-retinal services of the Kyorin Eye Center in 2010. Dr Rii's research interest is in the pathophysiology and imaging of vitreoretinal diseases.