Original articleDistribution of Retinal Layer Atrophy in Patients With Parkinson Disease and Association With Disease Severity and Duration
Section snippets
Patients and Methods
This was an observational, prospective, longitudinal study. The study and data accumulation were performed with approval from the Miguel Servet Hospital Institutional Review Board (IRB). The authors confirm that the study and data accumulation conformed to all country, federal, or state laws, and the study adhered to the tenets of the Declaration of Helsinki. Informed consent for the research was obtained from the patients or subjects.
Required inclusion criteria were as follows: best-corrected
Results
One hundred twenty-nine eyes from 129 Parkinson disease patients (72 men and 57 women) and 129 eyes of 129 healthy individuals (72 men and 57 women) were included in the study. Disease duration ranged from 1-24 years with a median of 8.40 years since diagnosis. The ages of the Parkinson disease patients ranged from 40-80 years (mean 68.75) and the ages of healthy subjects ranged from 40-89 years (mean 69.01). Mean intraocular pressure was 14.56 mm Hg in the Parkinson disease group and 14.35 mm
Discussion
A reduction of retinal ganglion cells leads to a corresponding decrease in retinal and RNFL thickness that can be detected in Parkinson disease patients using OCT.20, 21 Aaker and associates reported a statistically significant reduction in macular thickness in Parkinson disease patients compared with controls based on spectral-domain OCT, but they did not segment the retinal layers.22 Altintaş and associates demonstrated that Parkinson disease severity was related to alterations in foveal
Elena Garcia-Martin, PhD, received her medical degree from Salamanca University, followed by a fellowship at Miguel Servet University Hospital and completed a formation period at St Paul's Eye Unit Royal Liverpool University Hospital. In 2010, she finished her PhD with honors. She is working in Neuro-Ophthalmology and external ocular diseases at Miguel Servet University Hospital. She had been engaged in numerous research related-activities and developing projects either in medical or basis
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Elena Garcia-Martin, PhD, received her medical degree from Salamanca University, followed by a fellowship at Miguel Servet University Hospital and completed a formation period at St Paul's Eye Unit Royal Liverpool University Hospital. In 2010, she finished her PhD with honors. She is working in Neuro-Ophthalmology and external ocular diseases at Miguel Servet University Hospital. She had been engaged in numerous research related-activities and developing projects either in medical or basis science research.
Luis E. Pablo, PhD, is a Professor of Ophthalmology and Optics at Zaragoza University in Spain. He completed his residency in ophthalmology in 1994. His areas of research interest are clinical and experimental glaucoma. Currently, Dr Pablo is Vice-Secretary-General of the Spanish Glaucoma Society and head of the Department of Ophthalmology at Miguel Servet University Hospital, Zaragoza, Spain.