Original articleAutologous Transplantation of the Internal Limiting Membrane for Refractory Macular Holes
Section snippets
Patients and Study Design
This study was a prospective, interventional case series. All investigations adhered to the tenets of the Declaration of Helsinki. Each patient was informed about the risks and benefits of the surgery and their written, informed consent was obtained. The study was approved by the Institutional Review Boards of Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Kagawa University Faculty of Medicine.
Ten eyes of 10 consecutive patients who had refractory
Results
The characteristics of the 10 patients who were enrolled in this study are shown in the Table. The mean age of the 6 female and 4 male patients was 60.6 ± 19.5 years (range, 17 to 83 years). The mean follow-up period was 12 ± 5 months (range, 3 to 18 months). The mean diameter of the macular holes before autologous transplantation of the ILM was 509.3 ± 137.8 μm (range, 281 to 789 μm). The lens status of the eyes was unchanged after autologous transplantation of the ILM. Intraocular lenses had
Discussion
Recently, several surgical procedures that intentionally spare the foveal ILM have been reported to be effective in conditions such as large macular holes, myopic macular holes, and myopic foveoschisis.2, 3, 4, 5 Although these procedures can be options for the initial vitrectomy, to avoid the failure of macular hole closure and the development of secondary macular holes, they cannot be the solution for eyes with macular holes from which the ILMs already have been removed in previous
Yuki Morizane, MD, PhD, is an Assistant Professor (Lecturer), Department of Ophthalmology, Okayama University, Okayama, Japan. After finishing his residency in ophthalmology and retina fellowship at Okayama University Hospital, he completed a retinal research fellowship at Harvard Medical School, Massachusetts Eye and Ear Infirmary from 2008 to 2011. His research interests are metabolic mechanisms of ocular diseases, ocular neovascularization, and vitrectomy.
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Yuki Morizane, MD, PhD, is an Assistant Professor (Lecturer), Department of Ophthalmology, Okayama University, Okayama, Japan. After finishing his residency in ophthalmology and retina fellowship at Okayama University Hospital, he completed a retinal research fellowship at Harvard Medical School, Massachusetts Eye and Ear Infirmary from 2008 to 2011. His research interests are metabolic mechanisms of ocular diseases, ocular neovascularization, and vitrectomy.
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