Original articleColor Fundus Photography Versus Fluorescein Angiography in Identification of the Macular Center and Zone in Retinopathy of Prematurity
Section snippets
Methods
This study was approved as a prospective study by the Institutional Review Board at Weill Cornell Medical College. Informed consent was obtained from all study participants before participation, and waiver of consent was obtained for use of de-identified retinal images. This study was conducted in accordance with Health Insurance Portability and Accountability Act guidelines.
Study Experts
Among the 9 experts who consented to participate in the study, 6 (67%) were retina specialists and 3 (33%) were pediatric ophthalmologists. The experts have been practicing ophthalmology for a mean of 19 years (standard deviation, 8.6 years; range, 10 to 33 years). When asked if FA is safe in neonates and infants, all (9/9) responded “yes.” Each expert graded 32 images (16 color fundus photographs, 16 FA images) from 16 eyes, for a total of 288 readings of the macular center. Figure 2 reveals
Discussion
The key findings from this study are as follows. (1) There does not seem to be a statistically significant difference by ROP experts in identification of the macular center using color fundus photographs versus FA images. (2) There is a marginally significant improvement in sensitivity of zone diagnosis and no statistically significant difference in specificity of zone diagnosis when using color fundus photographs compared with using color fundus photographs with the corresponding FA images.
Samir N. Patel is a medical student at Weill Cornell Medical College. He received his BS in Biology and Economics from Pennsylvania State University. He is expecting his MD degree in May 2016.
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2018, Journal of AAPOSCitation Excerpt :Zone I ROP was correctly identified only half the time by two readers, whereas TR3 had a much higher sensitivity, identifying zone I ROP correctly two-thirds of the time. Locating the foveal center on color images of preterm infants is challenging and extremely variable, even among ROP specialists.16,17 In our study, even when two independent grading results agreed on the presence of zone I ROP, only half of such results agreed with the clinical examination.
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Samir N. Patel is a medical student at Weill Cornell Medical College. He received his BS in Biology and Economics from Pennsylvania State University. He is expecting his MD degree in May 2016.
R.V. Paul Chan, MD, FACS is the St. Giles Associate Professor of Pediatric Retina, Associate Professor of Ophthalmology, and Director of the Retina Service at Weill Cornell Medical College. Dr Chan's clinical practice is in adult and pediatric retina. His research focuses on utilizing new technology and imaging techniques to better evaluate and manage pediatric retinal disease.