Original articleClassification Criteria For Multiple Evanescent White Dot Syndrome
Section snippets
METHODS
The SUN Developing Classification Criteria for the Uveitides project proceeded in 4 phases as previously described: 1) informatics, 2) case collection, 3) case selection, and 4) machine learning.15, 16, 17, 18
RESULTS
Ninety-five cases of MEWDS were collected, and 51 (54%) achieved supermajority agreement on the diagnosis during the “selection” phase and were used in the machine learning phase These cases of MEWDS were compared to cases of posterior uveitides, including 82 cases of APMPPE; 207 cases of BSCR; 122 cases of serpiginous choroiditis; 138 cases of MFCPU; 144 cases of PIC; 12 cases of sarcoid posterior uveitis; 35 cases of syphilitic posterior uveitis; and 277 cases of tubercular
DISCUSSION
The classification criteria developed by the SUN Working Group for MEWDS have an acceptable misclassification rate, indicating good discriminatory performance relative to other non-infectious posterior and panuveitides. Because the goal of the SUN criteria was classification at presentation and because MEWDS spontaneously resolves, these criteria were most appropriate for the early, active stage of the disease.20
Unlike other diseases in this class, the primary lesion appears to be at the level
CRediT roles
Douglas A. Jabs, MD, MBA: Conceptualization, Methodology, Validation, Investigation, Data curation, Writing–Review and editing, Visualization, Supervision, Project administration, Funding acquisition. Antoine P. Brezin, MD: Investigation, Writing–Review and editing. Andrew D. Dick, MBBS, MD, FRCP, FRCS, FRCOphth: Investigation, Writing–Review and editing. Ralph D. Levinson, MD: Investigation, Writing–Review and editing. Lyndell L. Lim, MD: Investigation, Writing–Review and editing. Peter
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2022, American Journal of OphthalmologyClinical features and possible pathogenesis of multiple evanescent white dot syndrome with different retinal diseases and events: a narrative review
2024, International Journal of OphthalmologyComparison of clinical findings and subjective symptoms in a case of multiple evanescent white dot syndrome (MEWDS): A case report from a patient's perspective
2024, Journal of General and Family Medicine
Supplemental Material available at AJO.com.
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Writing Committee: Douglas A. Jabs, Antoine P. Brezin, Andrew D. Dick, Ralph D. Levinson, Lyndell L. Lim, Peter McCluskey, Neal Oden, Alan G. Palestine, Jennifer E. Thorne, Brett E. Trusko, Albert Vitale, and Susan E. Wittenberg.
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Writing Committee Affiliations: Members of the SUN Working Group are listed online at AJO.com. Department of Epidemiology (D.A.J., J.E.T.), the Johns Hopkins University Bloomberg School of Public Health, and the Wilmer Eye Institute, Department of Ophthalmology (D.A.J., J.E.T.), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Ophthalmology (A.P.B.), University of Paris V-Hôpital Cochin, Paris, France; Academic Unit of Ophthalmology (A.D.D.), Bristol Medical School, University of Bristol, Bristol, UK; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital (A.D.D.), London, UK; University College London Institute of Ophthalmology (A.D.D.), London UK; Stein Eye Institute and Department of Ophthalmology (R.D.L.), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA; Center for Eye Research Australia (L.L.L.), Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; Save Sight Institute (P.M.), Department of Ophthalmology, University of Sydney School of Medicine, Sydney, New South Wales, Australia; Emmes Co, LLC, (N.O.) Rockville, Maryland, USA; Department of Ophthalmology (A.G.P.), University of Colorado School of Medicine, Aurora, Colorado, USA; Department of Medicine (B.E.T.), Texas A&M University, College Station, Texas, USA; Department of Ophthalmology (A.V.), University of Utah School of Medicine, Salt Lake City, Utah, USA; and the Houston Eye Associates (S.E.W.), Houston, Texas, USA.
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Financial Disclosures: Douglas A. Jabs: none. Antoine Brezin: none. Andrew Dick: none. Ralph Levinson: none. Lyndell L. Lim: none. Peter McCluskey: none. Neal Oden: none. Alan G. Palestine: none. Jennifer E. Thorne: Dr. Thorne engaged in a portion of this research as a consultant and was compensated for the consulting service; Brett E. Trusko: none. Albert Vitale: none. Susan E. Wittenberg: none.
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Inquiries to: Douglas A. Jabs, Department of Epidemiology, the Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 20215 USA. E-mail: [email protected].