American Journal of Orthodontics and Dentofacial Orthopedics
Original articleMI Paste Plus to prevent demineralization in orthodontic patients: A prospective randomized controlled trial
Section snippets
Material and methods
The study protocol was reviewed and approved by the institutional review board of the University of Texas Health Science Center at Houston.
Sixty from a possible 65 patients who were undergoing routine orthodontic treatment were recruited for this prospective double-blind randomized clinical trial. The patients were 12 years of age and older. A caries risk assessment was used to determine their caries risks. They were carefully selected for the study and included and excluded on the following
Results
This study was a prospective clinical trial with a double blind method of randomization. We found that MI Paste Plus, used as presented here, not only lessened the occurrence of white spots, but also actually reduced the number of white spots already present. The results of the statistical analysis are presented in Table II, and the reduction in scores in Tables III and IV.
The subjects were recruited over a 1-year period. Sixty-five patients who expressed an interest were approached to
Discussion
White spot lesion formation is frequently encountered in orthodontic patients.4, 5, 6, 7, 8, 9 The roles of dental materials, such as glass ionomer and resin sealants, in inhibiting demineralization have been well documented and are well accepted as a standard of care. The benefit of topical fluoride in reducing demineralization and supporting remineralization is well recognized. Considerable research has been devoted to fluoride delivery methods that reduce or minimize enamel demineralization
Conclusions
The following results can be drawn from this randomized controlled trial.
- 1.
MI Paste Plus not only had a preventive action of white spot development during orthodontic treatment, but also decreased the number of white spot lesions.
- 2.
The placebo had no preventive action on white spot development during orthodontic treatment; the number of lesions actually increased.
- 3.
MI Paste Plus had an impact on reducing white spots on the gingival surfaces, whereas the placebo group had the opposite effect.
- 4.
The
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The authors report no commercial, proprietary, or financial interest in the products or companies described in this article.