Transactions from the Thirty-Second Annual Scientific Meeting of the Society of Gynecologic SurgeonsThe impact of the overactive bladder syndrome on sexual function: A preliminary report from the Multicenter Assessment of Transdermal Therapy in Overactive Bladder with Oxybutynin trial
Section snippets
Material and methods
The Multicenter Assessment of Transdermal Therapy in Overactive Bladder with Oxybutynin (MATRIX) study was an open-label, 6-month, randomized, multicenter, prospective, community-based trial of subjects with OAB. All participants received the Food and Drug Administration–approved 3.9 mg/day transdermal oxybutynin matrix patch changed twice weekly (every 3 to 4 days) for the duration of the study. Sites were randomly assigned in a 1:1 ratio to have enrolled participants either receive additional
Results
The demographics of the study population are shown in Table I. Among the 2878 subjects with OAB recruited at 327 centers, the mean age was 62.5 years (± 14.8 years), 2508 of the patients (87.2%) were female, of whom 2104 (84%) were postmenopausal (ie, no pregnancy test was required or performed), and 2406 (83.6%) were Caucasian. At baseline, 1334 participants (46.4%) reported experiencing OAB symptoms for 4 years or longer, whereas 346 (12.0%) had experienced symptoms for 1 year or less. Of the
Comment
The degree to which OAB symptoms affect sexual function may be influenced by physiologic, psychosocial, or socioeconomic factors in addition to disease severity. Specific bladder symptoms may cause embarrassment and a resultant decrease in sexual interest. This may have a profound effect on an incontinent patient's marital or conjugal relationships. Yip et al4 compared 29 women with detrusor overactivity on urodynamic testing with those with normal urodynamics (28 women) and found a
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Coital incontinence
2018, Progres en UrologieOnabotulinumtoxinA detrusor injection improves female sexual function in women with overactive bladder wet syndrome
2018, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :Quality of life for women with OAB is significantly affected at different levels, and it is quite likely that sexual function is also affected [22,23]. In the last decade, several studies have found a relevant improvement in sexual function by treatment of OAB with anticholinergics [24–26]. However, other studies did not find a significant association between improvement in OAB symptoms and sexual function [27].
Does the Severity of Overactive Bladder Symptoms Correlate With Risk for Female Sexual Dysfunction?
2017, Journal of Sexual MedicineCitation Excerpt :Urinary frequency alone was not associated with any domain in the FSFI, confirming a previous finding.28 Many previous studies have reported that women with OAB and urinary incontinence have some problems during sexual functioning.4,28–30 Zahariou et al25 compared the FSFI with OAB diagnosed by urodynamics and the International Continence Society criteria; Shindel et al12 compared the FSFI with an OAB questionnaire (with no measurement of OAB severity); and Musco et al11 performed a pilot study with women who underwent percutaneous tibial nerve stimulation and did not find an association between OAB severity and different degrees of FSFI score.
The value of oxybutynin in transdermal patches for treating overactive bladder
2015, Actas Urologicas EspanolasAntimuscarinic use and discontinuation in an older adult population
2019, Archives of Gerontology and GeriatricsCitation Excerpt :Overactive bladder (OAB) is characterized by urination with a sense of urgency, frequency of urination, and nocturia, with or without incontinence. ( Gormley, Lightner, & Burgio, 2014) OAB can negatively impact a patient’s quality of life including social interactions, sexual function, sleep, and mental health (Coyne, Payne, & Bhattacharyya, 2004; Hullfish et al., 2007; Liberman, Hunt, & Stewart, 2001; Melville, Delaney, Newton, & Katon, 2005; Sand, Goldberg, Dmochowski, McIlwain, & Dahl, 2006; Sexton et al., 2011; Wyman, Harkins, Choi, Taylor, & Fantl, 1987). Symptoms of OAB increase with age as approximately one-third of adults aged 65 or older expressed symptoms suggestive of OAB (Stewart, Van Rooyen, & Cundiff, 2003).
Urinary symptoms and female sexual dysfunction in women with type 1 diabetes: the role of depression
2023, Journal of Sexual Medicine
Supported by Watson Laboratories (Morristown, NJ).
Presented at the Thirty-Second Annual Meeting of the Society of Gynecologic Surgeons, April 3-5, 2006, Tucson, AZ.