ResearchUrogynecologyFate of collagen-based implants used in pelvic floor surgery: A 2-year follow-up study in a rabbit model
Section snippets
Studied implants and experimental animals
We used 3 types of implants. Prolene PM-S (Ethicon, Dilbeek, Belgium) is a nonabsorbable monofilament polypropylene implant with large pore size (1500 μm) and a density of 85 g/cm2. Surgisis (SIS; Cook) is a porcine small intestinal submucosa derived acellular noncrosslinked xenograft. We used the 4-layer graft, which was at that time the marketed product for pelvic floor reconstruction. Pelvicol (Bard) is another porcine acellular yet dermal collagen and elastin matrix crosslinked with
Macroscopy
All animals had an uneventful postoperative recovery, except 4 rabbits (180 days: n = 1; 540 days: n = 3) who died before sacrifice. Postmortem examination did not reveal any abnormalities at the implant site nor the cause of death. Observations from these animals were excluded from further analysis; however, in retrospect, inclusion would not have affected results. In 1 rabbit (Pelvicol 60 day group) there was a seropurulent subcutaneous collection on the Pelvicol implant. On histology, the
Comment
In a 2-year follow-up study we compared different xenogenic collagen constructs to polypropylene when used to cover abdominal wall defects in rabbits. Prolene induces a persisting chronic inflammatory response, with moderate numbers of FBGCs in a permanent fibrotic scar, coinciding with increasing tensiometric strength. SIS is degraded in a proportionally strong chronic inflammatory reaction, which tapers off by 3 months. The material is replaced within 60 days by a markedly thin and weak layer
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Cite this article as: Claerhout F, Verbist G, Verbeken E, et al. Fate of collagen-based implants used in pelvic floor surgery: A 2-year follow-up study in a rabbit model. Am J Obstet Gynecol 2008;198:94.e1-94.e6.