American Journal of Obstetrics and Gynecology
ResearchOncologyA multicentric trial (Olympia–MITO 13) on the accuracy of laparoscopy to assess peritoneal spread in ovarian cancer
Section snippets
Study design
Olympia-MITO 13 is a prospective multicentric trial registered (ClinicalTrials.gov, no. NCT01595204). Each center obtained the approval of the local ethical committee before enrolling patients. The design of the study is shown in Figure 1.
Women with first clinical and/or radiological diagnosis of advanced ovarian/fallopian tube or primary peritoneal cancer (International Federation of Gynecology and Obstetrics stages III-IV) were consecutively evaluated by a gynecologic oncologist who proposed
Results
From March 2010 to March 2012, 24 SCs agreed to participate to the prospective multicentric trial Olympia-MITO 13 (protocol identification NCT01595204). Seventeen (70.8%) did actually enroll patients. One hundred sixty-eight cases with suspicious primary advanced ovarian/peritoneal cancer were considered eligible for the study. Three women (1.8%) refused S-LPS and were then excluded. The remaining patients were submitted to S-LPS at the SCs, and no intraoperative complications were registered.
Comment
In the light of some recent advances in ovarian cancer treatment,19, 20, 21 the correct timing to perform debulking surgery is a crucial point in the natural history of the disease.
In this context, the availability of a minimally invasive approach, such as S-LPS, able to directly visualize intraperitoneal cavity as the preferred site of ovarian cancer diffusion, is a great diagnostic opportunity for the surgeon to draw a more individualized management of AOC. However, the introduction of a
References (22)
- et al.
A contemporary analysis of the ability of preoperative serum Ca-125 to predict primary cytoreductive outcome in patients with advanced ovarian, tubal and peritoneal carcinoma
Gynecol Oncol
(2009) - et al.
Complete cytoreductive surgery is feasible and maximizes survival in patients with advanced epithelial ovarian cancer
Gynecol Oncol
(1998) - et al.
Role of laparoscopy to assess the chance of optimal cytoreductive surgery in advanced ovarian cancer: a pilot study
Gynecol Oncol
(2005) - et al.
Prospective validation of a laparoscopic predictive model for optimal cytoreduction in advanced ovarian carcinoma
Am J Obstet Gynecol
(2008) - et al.
External validation of a laparoscopic-based score to evaluate respectability of advanced ovarian cancers: clues for a simplified score
Gynecol Oncol
(2008) Optimal two stage design for phase II clinical trials
Control Clin Trials
(1989)- et al.
Cancer statistics 2012
CA Cancer J Clin
(2012) - et al.
Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis
J Clin Oncol
(2002) - et al.
Impact of complete cytoreduction leaving no gross residual disease associated with radical cytoreductive surgical procedures on survival in advanced ovarian cancer
Ann Surg Oncol
(2012) - et al.
Optimal primary surgical treatment for advanced epithelial ovarian cancer
Cochrane Database Syst Rev
(2011)
Does neoadjuvant chemotherapy increase optimal cytoreduction rate in advanced ovarian cancer? Meta-analysis of 21 studies
Ann Surg Oncol
Cited by (114)
Distribution and prognostic role of BRCA status in elderly ovarian cancer patients
2024, Gynecologic OncologyPeritonectomy and resection of mesentery during Visceral-Peritoneal Debulking (VPD) in patients with stage IIIC-IV ovarian cancer: A phase I-II trial
2024, European Journal of Surgical OncologyRole of minimally invasive surgery in gynecologic malignancies
2023, DiSaia and Creasman Clinical Gynecologic OncologyPreliminary observational study of the implementation of hyperthermic intraperitoneal chemotherapy in ovarian cancer in the gynecological surgery department at the University Hospital of Strasbourg
2023, Journal of Gynecology Obstetrics and Human ReproductionSurgical management of patients with advanced ovarian cancer: Results of a French National Survey
2022, Journal of Gynecology Obstetrics and Human Reproduction
The authors report no conflict of interest.
Cite this article as: Fagotti A, Vizzielli G, De Iaco P, et al. A multicentric trial (Olympia–MITO 13) on the accuracy of laparoscopy to assess peritoneal spread in ovarian cancer. Am J Obstet Gynecol 2013;209:462.e1-11.