Review and special articlesLong-term effectiveness of weight-loss interventions in adults with pre-diabetes: A review
Section snippets
Data sources
Following the Cochrane Collaboration’s methods,13 a systematic review protocol was developed. In consultation with a medical research librarian, search strategies were devised using an iterative process that involved medical subject headings (MeSH) and text words. The following databases were searched between the date indicated and August 2003: MEDLINE (1966), EMBASE (1980), CINAHL (1982), ERIC (1966), PsychInfo (1967), Web of Science (1981), Biosis (1969), Nutrition Abstracts and Reviews
Results
Nine eligible RCTs were identified in the published literature10, 11, 21, 22, 23, 24, 25, 26, 27 (Table 1). These were all weight-loss studies among overweight or obese people with pre-diabetes. No unpublished studies were identified and no studies focused exclusively on weight control. The study flow diagram is available from the authors. The studies included a total of 5168 participants (range, 31 to 3234) and the follow-up interval averaged 3.2 years. The study populations varied somewhat in
Discussion and conclusions
Randomized controlled trials of weight-loss interventions using dietary, physical activity, or behavioral interventions produced statistically significant between-group weight loss of 2 to 3 kg (3% of initial body weight) at 1- and 2-year follow-ups. In two studies where weight was examined at longer follow-up intervals (up to 10 years), similar weight reduction was maintained. The number of intervention contacts with subjects was significantly correlated with weight loss. Data are limited, but
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