Brief report
Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus

https://doi.org/10.1016/j.amjcard.2003.08.033Get rights and content

Abstract

Hyperglycemia has been linked to adverse outcomes after myocardial infarction. We characterized the effect of selected concentrations of glucose or mannitol on platelet function in whole blood samples from healthy volunteers and from patients with and without diabetes mellitus. Activation of platelet glycoprotein IIb/IIIa and P-selectin expression was increased similarly after addition of isosmotic concentrations of glucose and mannitol, suggesting that increased osmolarity associated with hyperglycemia increases platelet reactivity.

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This report was supported in part by grant R01-HL69146 from the National Institutes of Health, Bethesda, Maryland.

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