Coronary artery diseaseNoninvasive Assessment of Coronary Plaque Burden Using Multislice Computed Tomography
Section snippets
Methods
Over a 4-month period, 85 patients who had stable angina pectoris underwent 16-row MSCT coronary angiography and conventional coronary angiography. Patients were eligible for inclusion if they were in sinus rhythm with a heart rate of <70 beats/min (spontaneously or after oral β blockade), and were able to hold their breath for 20 seconds. Patients who had known allergy to contrast media, impaired renal function (serum creatinine >120 mmol/L), acute coronary syndromes, and previous coronary
Results
Over a 4-month period, 85 eligible patients who had stable angina underwent multislice computed tomography. The mean interval between conventional coronary angiography and multislice computed tomography was 13 ± 5.2 days. Multislice computed tomograms were not of diagnostic quality in 7 patients. Motion artifacts were present in 6 patients due to premature beats2 or residual motion despite a heart rate of <70 beats/min.4 Extravasation of contrast material during the injection resulted in low
Discussion
The major objectives of noninvasive imaging of coronary arteries are to identify significant luminal stenoses and to identify plaques that may become responsible for an acute coronary syndrome.
The diagnostic performance of current 16-row MSCT scanners in the detection of significant (>50% luminal decrease) coronary plaques has been reported.12, 13, 14 The sensitivity has been reported to be 92% to 95% with a specificity of 86% to 93% compared with invasive conventional coronary angiography. Our
References (23)
- et al.
Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography
J Am Coll Cardiol
(2001) - et al.
Composition of coronary atherosclerotic plaques in patients with acute myocardial infarction and stable angina pectoris determined by contrast-enhanced multislice computed tomography
Am J Cardiol
(2003) - et al.
Accuracy of multidetector spiral computed tomography in identifying and differentiating the composition of coronary atherosclerotic plaques: a comparative study with intracoronary ultrasound
J Am Coll Cardiol
(2004) - et al.
Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries
Atherosclerosis
(2004) - et al.
Advances in cardiac imaging with 16-section CT systems
Acad Radiol
(2003) - et al.
Multislice spiral CT coronary angiography in patients with stable angina pectoris
J Am Coll Cardiol
(2004) - et al.
Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology
J Am Coll Cardiol
(1998) - et al.
Comparison of electron-beam computed tomography and intracoronary ultrasound in detecting calcified and noncalcified plaques in patients with acute coronary syndromes and no or minimal to moderate angiographic coronary artery disease
Am J Cardiol
(1998) - et al.
Comparison of electron beam computed tomography with intracoronary ultrasound and coronary angiography for detection of coronary atherosclerosis
J Am Coll Cardiol
(1997) - et al.
Noninvasive definition of anatomic coronary artery disease by ultrafast computed tomographic scanning: a quantitative pathologic comparison study
J Am Coll Cardiol
(1992)
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