Coronary artery diseaseRelation of Timing of Cardiac Catheterization to Outcomes in Patients With Non–ST-Segment Elevation Myocardial Infarction or Unstable Angina Pectoris Enrolled in the Multinational Global Registry of Acute Coronary Events
Section snippets
Methods
Full details of the Global Registry of Acute Coronary Events methods have been published (www.outcomes.org/grace).11, 12, 13 Currently, 94 hospitals in 14 countries are participating in the Global Registry of Acute Coronary Events. Patients entered in the registry had to be ≥18 years old and alive at the time of hospital presentation, be admitted for ACS as a presumptive diagnosis (i.e., have symptoms consistent with acute ischemia), and have ≥1 of the following: electrocardiographic changes
Patient characteristics
A total of 33,202 patients who had ACS were enrolled in the Global Registry of Acute Coronary Events between April 1999 and September 2003. Of these, 11,281 were diagnosed with unstable angina pectoris and 9,775 with NSTEMI. Of patients who had unstable angina pectoris and NSTEMI, 51.6% underwent catheterization. Data on the timing of catheterization were available in 8,853 patients who were then categorized into expeditive, early, and delayed catheterization groups (Table 1).
More than 66% of
Discussion
Observational data from large-scale registries such as the Global Registry of Acute Coronary Events have provided useful information about “real-life” patient populations and clinical management practices.13, 14 The present analysis used data from patients who had been hospitalized with a diagnosis of unstable angina pectoris or NSTEMI, had undergone early invasive management with standard catheterization procedures, and were enrolled in the Global Registry of Acute Coronary Events. Previously
Acknowledgment
The investigators express their gratitude to the physicians and nurses who participated in the Global Registry of Acute Coronary Events. Further information about the project and a complete list of the investigators can be found at www.outcomes.org/grace. Sanofi-Aventis, Bridgewater, New Jersey, had no involvement in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the report for publication.
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The Global Registry of Acute Coronary Events is funded by an unrestricted educational grant from Sanofi-Aventis, Bridgewater, New Jersey, to the Center for Outcomes Research, University of Massachusetts Medical School, Worcester, Massachusetts.