Heart failureUsefulness of Left Atrial Volume in Predicting First Congestive Heart Failure in Patients ≥65 Years of Age With Well-Preserved Left Ventricular Systolic Function
Section snippets
Study design and population
After obtaining study approval from the Mayo Foundation Institutional Review Board, potential subjects were identified from a computerized search of the echocardiographic database (after the exclusion of patients who had not provided authorization for the use of their clinical data in research). Search criteria were residence in Olmsted County, Minnesota; a record of ≥1 transthoracic echocardiogram performed at the Mayo Clinic, the Olmsted Medical Center, or their affiliated hospitals from
Results
We identified 1,495 Olmsted County residents (aged ≥65 years without a history of CHF, atrial fibrillation, stroke, valvular heart disease, congenital heart disease, or pacemaker implantation) who were referred for ≥1 echocardiographic study from 1990 to 1998. Of these patients, 1,375 (92%) had LV ejection fractions ≥50% at baseline and constituted the study population (811 women and 564 men). The mean age of the cohort was 75 ± 7 years. The referral indications included dyspnea and/or chest
Discussion
In this study involving an elderly cohort with well-preserved LV systolic function referred for echocardiographic study, a considerable proportion (10%) developed first CHF within 5 years of follow-up. The incidence rate of CHF was slightly higher than that reported for the participants in the Cardiovascular Health Study (also aged ≥65 years),9 probably because of the referral-based nature of our study population. In most patients who developed CHF in our study, systolic function remained
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This study was supported by the American Heart Association, Dallas, Texas, and the American Society of Echocardiography, Raleigh, North Carolina.